Animal models of tuberculosis: Zebrafish

L.M. van Leeuwen, A.M. van der Sar, W. Bitter

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)


Over the past decade the zebrafish (Danio rerio) has become an attractive new vertebrate model organism for studying mycobacterial pathogenesis. The combination of mediumthroughput screening and real-time in vivo visualization has allowed new ways to dissect host pathogenic interaction in a vertebrate host. Furthermore, genetic screens on the host and bacterial sides have elucidated new mechanisms involved in the initiation of granuloma formation and the importance of a balanced immune response for control of mycobacterial pathogens. This article will highlight the unique features of the zebrafish-Mycobacterium marinum infection model and its added value for tuberculosis research.
Original languageEnglish
Article numbera018580
JournalCold Spring Harbor perspectives in medicine
Issue number3
Publication statusPublished - 2015

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