Antimetabolites in the treatment of arthritis: current status of the use of antimetabolites

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by a chronic inflammation of the synovial joints and infiltration of blood-derived cells. In daily practice rheumatologists use the antimetabolites methotrexate (MTX) and leflunomide for the treatment of patients with rheumatoid arthritis. The current clinical status (efficacy/toxicity) of these 2 antimetabolites in the treatment of RA will be discussed.

Original languageEnglish
Pages (from-to)1083-8
Number of pages6
JournalNucleosides, Nucleotides and Nucleic Acids
Issue number8-9
Publication statusPublished - Oct 2004


  • Antimetabolites/therapeutic use
  • Antirheumatic Agents/therapeutic use
  • Arthritis, Rheumatoid/drug therapy
  • Humans
  • Isoxazoles/therapeutic use
  • Leflunomide
  • Methotrexate/therapeutic use
  • Time Factors

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