Antimicrobial treatment of infective endocarditis caused by viridans streptococci highly susceptible to penicillin: historic overview and future considerations

D. W. M. Verhagen; A. C. Vedder; P. Speelman; J. T. M. van der Meer

doi:https://doi.org/10.1093/jac/dkl087

Antimicrobial treatment of infective endocarditis caused by viridans streptococci highly susceptible to penicillin: historic overview and future considerations

D. W. M. Verhagen, A. C. Vedder, P. Speelman, J. T. M. van der Meer

Research output: Contribution to journal › Review article › Academic › peer-review

19 Citations (Scopus)

Abstract

In this article we present the path that led to current concepts regarding antimicrobial treatment of endocarditis caused by viridans streptococci highly susceptible to penicillin. Early treatment trials indicate that some patients with subacute endocarditis can be cured with shorter treatment duration than currently advised by international guidelines. Also, high-dose antibiotics, as recommended today, have a predominantly pharmacokinetic and pharmacodynamic rationale that is based mostly on experimental animal studies. Shortening antimicrobial treatment in select patients with endocarditis would be of great benefit. As yet there are no predictors of cure that can be used to individualize treatment duration in patients with bacterial endocarditis

Original language	English
Pages (from-to)	819-824
Journal	Journal of antimicrobial chemotherapy
Volume	57
Issue number	5
DOIs	https://doi.org/10.1093/jac/dkl087
Publication status	Published - 2006

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https://doi.org/10.1093/jac/dkl087

Cite this

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title = "Antimicrobial treatment of infective endocarditis caused by viridans streptococci highly susceptible to penicillin: historic overview and future considerations",

abstract = "In this article we present the path that led to current concepts regarding antimicrobial treatment of endocarditis caused by viridans streptococci highly susceptible to penicillin. Early treatment trials indicate that some patients with subacute endocarditis can be cured with shorter treatment duration than currently advised by international guidelines. Also, high-dose antibiotics, as recommended today, have a predominantly pharmacokinetic and pharmacodynamic rationale that is based mostly on experimental animal studies. Shortening antimicrobial treatment in select patients with endocarditis would be of great benefit. As yet there are no predictors of cure that can be used to individualize treatment duration in patients with bacterial endocarditis",

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Antimicrobial treatment of infective endocarditis caused by viridans streptococci highly susceptible to penicillin: historic overview and future considerations. / Verhagen, D. W. M.; Vedder, A. C.; Speelman, P. et al.
In: Journal of antimicrobial chemotherapy, Vol. 57, No. 5, 2006, p. 819-824.

Research output: Contribution to journal › Review article › Academic › peer-review

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