TY - JOUR
T1 - Aortic pulse wave velocity in individuals of Asian and African ancestry
T2 - the HELISUR study
AU - Diemer, Frederieke S.
AU - Baldew, Se Sergio M.
AU - Haan, Yentl C.
AU - Karamat, Fares A.
AU - Oehlers, Glenn P.
AU - van Montfrans, Gert A.
AU - van den Born, Bert Jan H.
AU - Peters, Ron J.G.
AU - Nahar-Van Venrooij, Lenny M.W.
AU - Brewster, Lizzy M.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Aortic pulse wave velocity has emerged as an important predictor of cardiovascular events, but data on ethnic differences in pulse wave velocity remain scarce. We explored differences in pulse wave velocity between people of Asian and African ancestry. Data were used from the cross-sectional Healthy Life in Suriname (HELISUR) study. Pulse wave velocity was estimated oscillometrically with the Arteriograph. We included 353 Asians and 364 Africans, aged respectively 44.9 (SD 13.5) and 42.8 (SD 14.1) years (p = 0.05). Crude median PWV was higher in Asians than in Africans (8.1 [IQR 6.9–10.1] m/s vs. 7.7 [IQR 6.5–9.3] m/s, p = 0.03), which was mainly attributable to an increased PWV in Asians ≥ 50 years (10.1 [IQR 8.7–11.8] m/s vs. 9.1 [IQR 7.9–11.3] m/s in Africans ≥50 years, p < 0.01). After adjustment for age and MAP in multivariable linear regression, Asians had a 1.044 [95% CI 1.019–1.072] m/s higher PWV compared to Africans. Additional adjustment for sex, glucose, total cholesterol, HDL cholesterol, triglycerides, BMI, and waist circumference did not substantially change the difference in pulse wave velocity between Asians and Africans (+1.044 [95% CI 1.016–1.074] m/s for Asians vs. Africans). In conclusion, persons of Asian ancestry have a higher pulse wave velocity than those of African ancestry. This persisted after adjustment for important cardiovascular risk parameters, including age and blood pressure. The higher PWV found in Asians could be consistent with their increased coronary heart disease risk.
AB - Aortic pulse wave velocity has emerged as an important predictor of cardiovascular events, but data on ethnic differences in pulse wave velocity remain scarce. We explored differences in pulse wave velocity between people of Asian and African ancestry. Data were used from the cross-sectional Healthy Life in Suriname (HELISUR) study. Pulse wave velocity was estimated oscillometrically with the Arteriograph. We included 353 Asians and 364 Africans, aged respectively 44.9 (SD 13.5) and 42.8 (SD 14.1) years (p = 0.05). Crude median PWV was higher in Asians than in Africans (8.1 [IQR 6.9–10.1] m/s vs. 7.7 [IQR 6.5–9.3] m/s, p = 0.03), which was mainly attributable to an increased PWV in Asians ≥ 50 years (10.1 [IQR 8.7–11.8] m/s vs. 9.1 [IQR 7.9–11.3] m/s in Africans ≥50 years, p < 0.01). After adjustment for age and MAP in multivariable linear regression, Asians had a 1.044 [95% CI 1.019–1.072] m/s higher PWV compared to Africans. Additional adjustment for sex, glucose, total cholesterol, HDL cholesterol, triglycerides, BMI, and waist circumference did not substantially change the difference in pulse wave velocity between Asians and Africans (+1.044 [95% CI 1.016–1.074] m/s for Asians vs. Africans). In conclusion, persons of Asian ancestry have a higher pulse wave velocity than those of African ancestry. This persisted after adjustment for important cardiovascular risk parameters, including age and blood pressure. The higher PWV found in Asians could be consistent with their increased coronary heart disease risk.
UR - http://www.scopus.com/inward/record.url?scp=85058863766&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41371-018-0144-0
DO - https://doi.org/10.1038/s41371-018-0144-0
M3 - Article
C2 - 30568290
SN - 0950-9240
VL - 34
SP - 108
EP - 116
JO - Journal of human hypertension
JF - Journal of human hypertension
IS - 2
ER -