Apoptosis induces temporal increase in attenuation as measured by optical coherence tomography

Freek J. van der Meer, Dirk J. Faber, Maurice C. Aalders, Jop Perrée, Ton G. van Leeuwen

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review


Apoptosis is the effector of regulated cell death and plays a role in many physiologic and pathologic processes. In a previous study we demonstrated qualitatively that the scattering of the tissue, as observed by optical Coherence Tomography, is increased. In this study, we quantified the change in scattering in balloon dilatted ex vivo porcine arteries and in cell cultures after chemical induction of apoptosis. Furthermore, in the cell culture, necrosis was observed as an decrease in attenuation. These results indicate that the apoptotic process may be detected using OCT due to an increase in scattering by the typical disintegration of cellular material and can be differentiated from the necotic process. ©2005 Optical Society of America.
Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2005
PublisherOptical Society of America (OSA)
ISBN (Print)0819458635
Publication statusPublished - 2005
EventEuropean Conference on Biomedical Optics, ECBO 2005 - , Germany
Duration: 12 Jun 200512 Jun 2005

Publication series

NameOptics InfoBase Conference Papers


ConferenceEuropean Conference on Biomedical Optics, ECBO 2005

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