TY - GEN
T1 - Apoptosis induces temporal increase in attenuation as measured by optical coherence tomography
AU - van der Meer, Freek J.
AU - Faber, Dirk J.
AU - Aalders, Maurice C.
AU - Perrée, Jop
AU - van Leeuwen, Ton G.
PY - 2005
Y1 - 2005
N2 - Apoptosis is the effector of regulated cell death and plays a role in many physiologic and pathologic processes. In a previous study we demonstrated qualitatively that the scattering of the tissue, as observed by optical Coherence Tomography, is increased. In this study, we quantified the change in scattering in balloon dilatted ex vivo porcine arteries and in cell cultures after chemical induction of apoptosis. Furthermore, in the cell culture, necrosis was observed as an decrease in attenuation. These results indicate that the apoptotic process may be detected using OCT due to an increase in scattering by the typical disintegration of cellular material and can be differentiated from the necotic process. ©2005 Optical Society of America.
AB - Apoptosis is the effector of regulated cell death and plays a role in many physiologic and pathologic processes. In a previous study we demonstrated qualitatively that the scattering of the tissue, as observed by optical Coherence Tomography, is increased. In this study, we quantified the change in scattering in balloon dilatted ex vivo porcine arteries and in cell cultures after chemical induction of apoptosis. Furthermore, in the cell culture, necrosis was observed as an decrease in attenuation. These results indicate that the apoptotic process may be detected using OCT due to an increase in scattering by the typical disintegration of cellular material and can be differentiated from the necotic process. ©2005 Optical Society of America.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085401287&origin=inward
U2 - https://doi.org/10.1364/ecbo.2005.tue4
DO - https://doi.org/10.1364/ecbo.2005.tue4
M3 - Conference contribution
SN - 0819458635
T3 - Optics InfoBase Conference Papers
BT - European Conference on Biomedical Optics, ECBO 2005
PB - Optical Society of America (OSA)
T2 - European Conference on Biomedical Optics, ECBO 2005
Y2 - 12 June 2005 through 12 June 2005
ER -