TY - JOUR
T1 - Application of amniotic membranes in reconstructive surgery of internal organs—A systematic review and meta-analysis
AU - Maljaars, Lennart P.
AU - Bendaoud, Sohayla
AU - Kastelein, Arnoud W.
AU - Guler, Zeliha
AU - Hooijmans, Carlijn R.
AU - Roovers, Jan-Paul W. R.
N1 - Funding Information: We are grateful for the support of ZonMw (project number 114024902 and 114024164, the Netherlands) who provided a grant to promote Synthesis of Evidence of animal studies. Publisher Copyright: © 2022 The Authors. Journal of Tissue Engineering and Regenerative Medicine published by John Wiley & Sons Ltd.
PY - 2022/12
Y1 - 2022/12
N2 - Amniotic membrane (AM) has great potential as a scaffold for tissue regeneration in reconstructive surgery. To date, no systematic review of the literature has been performed for the applications of AM in wound closure of internal organs. Therefore, in this systematic review and meta-analysis, we summarize the literature on the safety and efficacy of AM for the closure of internal organs. A systematic search was performed in MEDLINE-PubMed database and OVID Embase to retrieve human and controlled animal studies on wound closure of internal organs. The Cochrane Risk of Bias tool for randomized clinical trials and the SYRCLE risk of bias tool for animal studies were used. Meta-analyses (MAs) were conducted for controlled animal studies to assess efficacy of closure, mortality and complications in subjects who underwent surgical wound closure in internal organs with the application of AM. Sixty references containing 26 human experiments and 36 animal experiments were included. The MAs of the controlled animal studies showed comparable results with regard to closure, mortality and complications, and suggested improved mechanical strength and lower inflammation scores after AM application when compared to standard surgical closure techniques. This systematic review and MAs demonstrate that the application of AM to promote wound healing of internal organs appears to be safe, efficacious, and feasible.
AB - Amniotic membrane (AM) has great potential as a scaffold for tissue regeneration in reconstructive surgery. To date, no systematic review of the literature has been performed for the applications of AM in wound closure of internal organs. Therefore, in this systematic review and meta-analysis, we summarize the literature on the safety and efficacy of AM for the closure of internal organs. A systematic search was performed in MEDLINE-PubMed database and OVID Embase to retrieve human and controlled animal studies on wound closure of internal organs. The Cochrane Risk of Bias tool for randomized clinical trials and the SYRCLE risk of bias tool for animal studies were used. Meta-analyses (MAs) were conducted for controlled animal studies to assess efficacy of closure, mortality and complications in subjects who underwent surgical wound closure in internal organs with the application of AM. Sixty references containing 26 human experiments and 36 animal experiments were included. The MAs of the controlled animal studies showed comparable results with regard to closure, mortality and complications, and suggested improved mechanical strength and lower inflammation scores after AM application when compared to standard surgical closure techniques. This systematic review and MAs demonstrate that the application of AM to promote wound healing of internal organs appears to be safe, efficacious, and feasible.
KW - amniotic membrane
KW - animal models
KW - hollow organ repair
KW - human studies
KW - internal organs
KW - reconstructive surgery
KW - surgical repair
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85141450645&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/term.3357
DO - https://doi.org/10.1002/term.3357
M3 - Review article
C2 - 36333859
SN - 1932-6254
VL - 16
SP - 1069
EP - 1090
JO - Journal of Tissue Engineering and Regenerative Medicine
JF - Journal of Tissue Engineering and Regenerative Medicine
IS - 12
ER -