Assessing clinical probability of pulmonary embolism: prospective validation of the simplified Geneva score

H. Robert-Ebadi; K. Mostaguir; M. M. Hovens; M. Kare; F. Verschuren; P. Girard; M. V. Huisman; F. Moustafa; P. W. Kamphuisen; H. R. Buller; M. Righini; G. Le Gal

doi:https://doi.org/10.1111/jth.13770

Assessing clinical probability of pulmonary embolism: prospective validation of the simplified Geneva score

H. Robert-Ebadi, K. Mostaguir, M. M. Hovens, M. Kare, F. Verschuren, P. Girard, M. V. Huisman, F. Moustafa, P. W. Kamphuisen, H. R. Buller, M. Righini, G. Le Gal

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19 Citations (Scopus)

Abstract

Essentials The simplified Geneva score allows easier pretest probability assessment of pulmonary embolism (PE). We prospectively validated this score in the ADJUST-PE management outcome study. The study shows that it is safe to manage patients with suspected PE according to this score. The simplified Geneva score is now ready for use in routine clinical practice. Background Pretest probability assessment by a clinical prediction rule (CPR) is an important step in the management of patients with suspected pulmonary embolism (PE). A limitation to the use of CPRs is that their constitutive variables and corresponding number of points are difficult to memorize. A simplified version of the Geneva score (i.e. attributing one point to each variable) has been proposed but never been prospectively validated. Aims Prospective validation of the simplified Geneva score (SGS) and comparison with the previous version of the Geneva score (GS). Methods In the ADJUST-PE study, which had the primary aim of validating the age-adjusted D-dimer cut-off, the SGS was prospectively used to determine the pretest probability in a subsample of 1621 study patients. Results Overall, PE was confirmed in 294 (18.1%) patients. Using the SGS, 608 (37.5%), 980 (60.5%) and 33 (2%) were classified as having a low, intermediate and high clinical probability. Corresponding prevalences of PE were 9.7%, 22.4% and 45.5%; 490 (30.1%) patients with low or intermediate probability had a D-dimer level below 500 μg L(-1) and 653 (41.1%) had a negative D-dimer test according to the age-adjusted cut-off. Using the GS, the figures were 491(30.9%) and 650 (40.9%). None of the patients considered as not having PE based on a low or intermediate SGS and negative D-dimer had a recurrent thromboembolic event during the 3-month follow-up. Conclusions The use of SGS has similar efficiency and safety to the GS in excluding PE in association with the D-dimer test

Original language	English
Pages (from-to)	1764-1769
Journal	Journal of thrombosis and haemostasis
Volume	15
Issue number	9
Early online date	2017
DOIs	https://doi.org/10.1111/jth.13770
Publication status	Published - 2017

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Robert-Ebadi, H., Mostaguir, K., Hovens, M. M., Kare, M., Verschuren, F., Girard, P., Huisman, M. V., Moustafa, F., Kamphuisen, P. W., Buller, H. R., Righini, M., & Le Gal, G. (2017). Assessing clinical probability of pulmonary embolism: prospective validation of the simplified Geneva score. Journal of thrombosis and haemostasis, 15(9), 1764-1769. https://doi.org/10.1111/jth.13770

@article{5696915c42cc41a0bca933d8f76a2ae7,

title = "Assessing clinical probability of pulmonary embolism: prospective validation of the simplified Geneva score",

abstract = "Essentials The simplified Geneva score allows easier pretest probability assessment of pulmonary embolism (PE). We prospectively validated this score in the ADJUST-PE management outcome study. The study shows that it is safe to manage patients with suspected PE according to this score. The simplified Geneva score is now ready for use in routine clinical practice. Background Pretest probability assessment by a clinical prediction rule (CPR) is an important step in the management of patients with suspected pulmonary embolism (PE). A limitation to the use of CPRs is that their constitutive variables and corresponding number of points are difficult to memorize. A simplified version of the Geneva score (i.e. attributing one point to each variable) has been proposed but never been prospectively validated. Aims Prospective validation of the simplified Geneva score (SGS) and comparison with the previous version of the Geneva score (GS). Methods In the ADJUST-PE study, which had the primary aim of validating the age-adjusted D-dimer cut-off, the SGS was prospectively used to determine the pretest probability in a subsample of 1621 study patients. Results Overall, PE was confirmed in 294 (18.1%) patients. Using the SGS, 608 (37.5%), 980 (60.5%) and 33 (2%) were classified as having a low, intermediate and high clinical probability. Corresponding prevalences of PE were 9.7%, 22.4% and 45.5%; 490 (30.1%) patients with low or intermediate probability had a D-dimer level below 500 μg L(-1) and 653 (41.1%) had a negative D-dimer test according to the age-adjusted cut-off. Using the GS, the figures were 491(30.9%) and 650 (40.9%). None of the patients considered as not having PE based on a low or intermediate SGS and negative D-dimer had a recurrent thromboembolic event during the 3-month follow-up. Conclusions The use of SGS has similar efficiency and safety to the GS in excluding PE in association with the D-dimer test",

author = "H. Robert-Ebadi and K. Mostaguir and Hovens, {M. M.} and M. Kare and F. Verschuren and P. Girard and Huisman, {M. V.} and F. Moustafa and Kamphuisen, {P. W.} and Buller, {H. R.} and M. Righini and {Le Gal}, G.",

year = "2017",

doi = "https://doi.org/10.1111/jth.13770",

language = "English",

volume = "15",

pages = "1764--1769",

journal = "Journal of thrombosis and haemostasis",

issn = "1538-7933",

publisher = "Wiley-Blackwell",

number = "9",

}

Robert-Ebadi, H, Mostaguir, K, Hovens, MM, Kare, M, Verschuren, F, Girard, P, Huisman, MV, Moustafa, F, Kamphuisen, PW , Buller, HR, Righini, M & Le Gal, G 2017, 'Assessing clinical probability of pulmonary embolism: prospective validation of the simplified Geneva score', Journal of thrombosis and haemostasis, vol. 15, no. 9, pp. 1764-1769. https://doi.org/10.1111/jth.13770

TY - JOUR

T1 - Assessing clinical probability of pulmonary embolism: prospective validation of the simplified Geneva score

AU - Robert-Ebadi, H.

AU - Mostaguir, K.

AU - Hovens, M. M.

AU - Kare, M.

AU - Verschuren, F.

AU - Girard, P.

AU - Huisman, M. V.

AU - Moustafa, F.

AU - Kamphuisen, P. W.

AU - Buller, H. R.

AU - Righini, M.

AU - Le Gal, G.

PY - 2017

Y1 - 2017

N2 - Essentials The simplified Geneva score allows easier pretest probability assessment of pulmonary embolism (PE). We prospectively validated this score in the ADJUST-PE management outcome study. The study shows that it is safe to manage patients with suspected PE according to this score. The simplified Geneva score is now ready for use in routine clinical practice. Background Pretest probability assessment by a clinical prediction rule (CPR) is an important step in the management of patients with suspected pulmonary embolism (PE). A limitation to the use of CPRs is that their constitutive variables and corresponding number of points are difficult to memorize. A simplified version of the Geneva score (i.e. attributing one point to each variable) has been proposed but never been prospectively validated. Aims Prospective validation of the simplified Geneva score (SGS) and comparison with the previous version of the Geneva score (GS). Methods In the ADJUST-PE study, which had the primary aim of validating the age-adjusted D-dimer cut-off, the SGS was prospectively used to determine the pretest probability in a subsample of 1621 study patients. Results Overall, PE was confirmed in 294 (18.1%) patients. Using the SGS, 608 (37.5%), 980 (60.5%) and 33 (2%) were classified as having a low, intermediate and high clinical probability. Corresponding prevalences of PE were 9.7%, 22.4% and 45.5%; 490 (30.1%) patients with low or intermediate probability had a D-dimer level below 500 μg L(-1) and 653 (41.1%) had a negative D-dimer test according to the age-adjusted cut-off. Using the GS, the figures were 491(30.9%) and 650 (40.9%). None of the patients considered as not having PE based on a low or intermediate SGS and negative D-dimer had a recurrent thromboembolic event during the 3-month follow-up. Conclusions The use of SGS has similar efficiency and safety to the GS in excluding PE in association with the D-dimer test

AB - Essentials The simplified Geneva score allows easier pretest probability assessment of pulmonary embolism (PE). We prospectively validated this score in the ADJUST-PE management outcome study. The study shows that it is safe to manage patients with suspected PE according to this score. The simplified Geneva score is now ready for use in routine clinical practice. Background Pretest probability assessment by a clinical prediction rule (CPR) is an important step in the management of patients with suspected pulmonary embolism (PE). A limitation to the use of CPRs is that their constitutive variables and corresponding number of points are difficult to memorize. A simplified version of the Geneva score (i.e. attributing one point to each variable) has been proposed but never been prospectively validated. Aims Prospective validation of the simplified Geneva score (SGS) and comparison with the previous version of the Geneva score (GS). Methods In the ADJUST-PE study, which had the primary aim of validating the age-adjusted D-dimer cut-off, the SGS was prospectively used to determine the pretest probability in a subsample of 1621 study patients. Results Overall, PE was confirmed in 294 (18.1%) patients. Using the SGS, 608 (37.5%), 980 (60.5%) and 33 (2%) were classified as having a low, intermediate and high clinical probability. Corresponding prevalences of PE were 9.7%, 22.4% and 45.5%; 490 (30.1%) patients with low or intermediate probability had a D-dimer level below 500 μg L(-1) and 653 (41.1%) had a negative D-dimer test according to the age-adjusted cut-off. Using the GS, the figures were 491(30.9%) and 650 (40.9%). None of the patients considered as not having PE based on a low or intermediate SGS and negative D-dimer had a recurrent thromboembolic event during the 3-month follow-up. Conclusions The use of SGS has similar efficiency and safety to the GS in excluding PE in association with the D-dimer test

U2 - https://doi.org/10.1111/jth.13770

DO - https://doi.org/10.1111/jth.13770

M3 - Article

C2 - 28688113

SN - 1538-7933

VL - 15

SP - 1764

EP - 1769

JO - Journal of thrombosis and haemostasis

JF - Journal of thrombosis and haemostasis

IS - 9

ER -