TY - JOUR
T1 - Assessment of system dysfunction in the brain through MRI-based connectomics
AU - Filippi, Massimo
AU - van den Heuvel, Martijn P.
AU - Fornito, Alexander
AU - He, Yong
AU - Hulshoff Pol, Hilleke E.
AU - Agosta, Federica
AU - Comi, Giancarlo
AU - Rocca, Maria A.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Network-based analysis of structural and functional connections has provided a new technique to study the brains of healthy people and patients with neurological and psychiatric disorders. Graph theory provides a powerful method to quantitatively describe the topological organisation of brain connectivity. With such a framework, the brain can be depicted as a set of nodes connected by edges. Distinct modifications of network topological organisation in the brain have been identified during development and normal ageing, whereas disrupted functional and structural connectivities have been associated with several neurological and psychiatric disorders, including dementia, amyotrophic lateral sclerosis, multiple sclerosis, and schizophrenia. These assessments have improved understanding of the clinical manifestations noted in these patients, including disability and cognitive impairment. Future network-based research might enable indentification of different stages of disorders, subtypes for cognitive impairment, and connectivity profiles associated with different clinical outcomes.
AB - Network-based analysis of structural and functional connections has provided a new technique to study the brains of healthy people and patients with neurological and psychiatric disorders. Graph theory provides a powerful method to quantitatively describe the topological organisation of brain connectivity. With such a framework, the brain can be depicted as a set of nodes connected by edges. Distinct modifications of network topological organisation in the brain have been identified during development and normal ageing, whereas disrupted functional and structural connectivities have been associated with several neurological and psychiatric disorders, including dementia, amyotrophic lateral sclerosis, multiple sclerosis, and schizophrenia. These assessments have improved understanding of the clinical manifestations noted in these patients, including disability and cognitive impairment. Future network-based research might enable indentification of different stages of disorders, subtypes for cognitive impairment, and connectivity profiles associated with different clinical outcomes.
UR - http://www.scopus.com/inward/record.url?scp=84887618546&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/S1474-4422(13)70144-3
DO - https://doi.org/10.1016/S1474-4422(13)70144-3
M3 - Review article
C2 - 24120645
SN - 1474-4422
VL - 12
SP - 1189
EP - 1199
JO - Lancet Neurology
JF - Lancet Neurology
IS - 12
ER -