TY - JOUR
T1 - Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)
AU - Nathan, Pradeep J.
AU - Lim, Yen Ying
AU - Abbott, Rosemary
AU - Galluzzi, Samantha
AU - Marizzoni, Moira
AU - Babiloni, Claudio
AU - Albani, Diego
AU - Bartres-Faz, David
AU - Didic, Mira
AU - Farotti, Lucia
AU - Parnetti, Lucilla
AU - Salvadori, Nicola
AU - Müller, Bernhard W.
AU - Forloni, Gianluigi
AU - Girtler, Nicola
AU - Hensch, Tilman
AU - Jovicich, Jorge
AU - Leeuwis, Annebet
AU - Marra, Camillo
AU - Molinuevo, José Luis
AU - Nobili, Flavio
AU - Pariente, Jeremie
AU - Payoux, Pierre
AU - Ranjeva, Jean Philippe
AU - Rolandi, Elena
AU - Rossini, Paolo Maria
AU - Schönknecht, Peter
AU - Soricelli, Andrea
AU - Tsolaki, Magda
AU - Visser, Pieter Jelle
AU - Wiltfang, Jens
AU - Richardson, Jill C.
AU - Bordet, Régis
AU - Blin, Olivier
AU - Frisoni, Giovanni B.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.
AB - Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) Aβ42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of Aβ42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/Aβ42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Aβ and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.
KW - Alzheimer's disease
KW - Amyloid
KW - CANTAB
KW - CSF
KW - Cognitive assessment
KW - Hippocampal volume
KW - Mild cognitive impairment
KW - Prodromal
KW - Tau
UR - http://www.scopus.com/inward/record.url?scp=85012085428&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neurobiolaging.2017.01.013
DO - https://doi.org/10.1016/j.neurobiolaging.2017.01.013
M3 - Article
C2 - 28189924
SN - 0197-4580
VL - 53
SP - 1
EP - 10
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -