TY - JOUR
T1 - Association between dexamethasone treatment and the host response in COVID-19 patients admitted to the general ward
AU - de Brabander, Justin
AU - Michels, Erik H. A.
AU - van Linge, Christine C. A.
AU - Chouchane, Osoul
AU - Amsterdam UMC COVID-19 biobank study group
AU - Douma, Renée A.
AU - Reijnders, Tom D. Y.
AU - Schuurman, Alex R.
AU - van Engelen, Tjitske S. R.
AU - Wiersinga, W. Joost
AU - van der Poll, Tom
N1 - Amsterdam UMC COVID-19 biobank study group Michiel A. van Agtmael, Anne Geke Algera, Brent Appelman, Frank E. H. P. van Baarle, Diane J. C. Bax, Martijn Beudel, Harm Jan Bogaard, Marije Bomers, Peter I. Bonta, Lieuwe D. J. Bos, Michela Botta, Justin de Brabander, Godelieve J. de Bree, Sanne de Bruin, Marianne Bugiani, Esther B. Bulle, Osoul Chouchane, Alex P. M. Cloherty, David T. P. Buis, Maurits C. F. J. de Rotte, Mirjam Dijkstra, Dave A. Dongelmans, Romein W. G. Dujardin, Paul E. Elbers, Lucas M. Fleuren, Suzanne E. Geerlings, Theo B. H. Geijtenbeek, Armand R. J. Girbes, Bram Goorhuis, Martin P. Grobusch, Florianne M. J. Hafkamp, Laura A. Hagens, Jörg Hamann, Vanessa C. Harris, Robert Hemke, Sabine M. Hermans, Leo M. A. Heunks, Markus W. Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Endry H. T. Lim, Niels van Mourik, Jeannine Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Dan A. I. Piña-Fuentes, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom D. Y. Reijnders, Michiel Schinkel, Femke A. P. Schrauwen, Marcus J. Schultz, Alex R. Schuurman, Jaap Schuurmans, Kim Sigalof, Marleen A. Slim, Patrick Smeele, Marry R. Smit, Cornelis S. Stijnis, Charlotte E. Teunissen, Patrick Thoral, Anissa M. Tsonas, Pieter R. Tuinman, Marc van der Valk, Denise P. Veelo, Carolien Volleman, Heder de Vries, Lonneke A. Vught, Michèle van Vugt, Dorien Wouters, Koos Zwinderman, Matthijs C. Brouwer, W. Joost Wiersinga, Alexander P. J. Vlaar & Diederik van de Beek
PY - 2022/6/3
Y1 - 2022/6/3
N2 - Dexamethasone improves clinical outcomes in COVID-19 patients requiring supplementary oxygen. We investigated possible mechanisms of action by comparing sixteen plasma host response biomarkers in general ward patients before and after implementation of dexamethasone as standard of care. 48 patients without and 126 patients with dexamethasone treatment were sampled within 48 h of admission. Endothelial cell and coagulation activation biomarkers were comparable. Dexamethasone treatment was associated with lower plasma interleukin (IL)-6 and IL-1 receptor antagonist levels, whilst other inflammation parameters were not affected. These data argue against modification of vascular-procoagulant responses as an early mechanism of action of dexamethasone in COVID-19.
AB - Dexamethasone improves clinical outcomes in COVID-19 patients requiring supplementary oxygen. We investigated possible mechanisms of action by comparing sixteen plasma host response biomarkers in general ward patients before and after implementation of dexamethasone as standard of care. 48 patients without and 126 patients with dexamethasone treatment were sampled within 48 h of admission. Endothelial cell and coagulation activation biomarkers were comparable. Dexamethasone treatment was associated with lower plasma interleukin (IL)-6 and IL-1 receptor antagonist levels, whilst other inflammation parameters were not affected. These data argue against modification of vascular-procoagulant responses as an early mechanism of action of dexamethasone in COVID-19.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131701717&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/35659223
UR - http://www.scopus.com/inward/record.url?scp=85131701717&partnerID=8YFLogxK
U2 - https://doi.org/10.1186/s12931-022-02060-3
DO - https://doi.org/10.1186/s12931-022-02060-3
M3 - Comment/Letter to the editor
C2 - 35659223
SN - 1465-993X
VL - 23
SP - 145
JO - Respiratory research
JF - Respiratory research
IS - 1
ER -