TY - JOUR
T1 - Association between season of vaccination and antibody levels against infectious diseases
AU - Abreu, T. C.
AU - Boshuizen, H.
AU - Mollema, L.
AU - Berbers, G. A. M.
AU - Korthals Altes, H.
PY - 2020
Y1 - 2020
N2 - Vaccination has reduced the disease burden of vaccine-preventable diseases. However, the extent to which seasonal cycles of immunity could influence vaccine-induced immunity is not well understood. A national cross-sectional serosurveillance study performed in the Netherlands (Pienter-2) yielded data to investigate whether season of vaccination was associated with antibody responses induced by DT-IPV (diphtheria, tetanus, and poliomyelitis), MMR (measles, mumps, and rubella), and meningococcus C (MenC) vaccines in children. 434 children met the inclusion criteria to study DT-IPV immunity, 811 for MMR, and 311 for MenC. Differences in log(antibody levels) by season of vaccination were investigated with linear multivariable regression analyses. Seroconversion rates varied according to season of vaccination for rubella (90% of autumn-vaccinated children vs. 99% of winter-vaccinated had concentrations above cut-off levels). Summer-vaccinated boys showed a slower decline of tetanus antibodies (6% per month), in comparison to winter-vaccinated boys. In conclusion, season of vaccination showed little association with immunological protection. However, a number of associations were seen with a p-value of about 0.03; and adding data from a just-completed nationwide serological study might add more power to the present study. Further immunological and longitudinal investigations could help understand the mechanisms of seasonal influence in vaccine-induced responses.
AB - Vaccination has reduced the disease burden of vaccine-preventable diseases. However, the extent to which seasonal cycles of immunity could influence vaccine-induced immunity is not well understood. A national cross-sectional serosurveillance study performed in the Netherlands (Pienter-2) yielded data to investigate whether season of vaccination was associated with antibody responses induced by DT-IPV (diphtheria, tetanus, and poliomyelitis), MMR (measles, mumps, and rubella), and meningococcus C (MenC) vaccines in children. 434 children met the inclusion criteria to study DT-IPV immunity, 811 for MMR, and 311 for MenC. Differences in log(antibody levels) by season of vaccination were investigated with linear multivariable regression analyses. Seroconversion rates varied according to season of vaccination for rubella (90% of autumn-vaccinated children vs. 99% of winter-vaccinated had concentrations above cut-off levels). Summer-vaccinated boys showed a slower decline of tetanus antibodies (6% per month), in comparison to winter-vaccinated boys. In conclusion, season of vaccination showed little association with immunological protection. However, a number of associations were seen with a p-value of about 0.03; and adding data from a just-completed nationwide serological study might add more power to the present study. Further immunological and longitudinal investigations could help understand the mechanisms of seasonal influence in vaccine-induced responses.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85097003989&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/33148351
U2 - https://doi.org/10.1017/S0950268820002691
DO - https://doi.org/10.1017/S0950268820002691
M3 - Article
C2 - 33148351
SN - 0950-2688
SP - 1
EP - 29
JO - Epidemiology and Infection
JF - Epidemiology and Infection
ER -