TY - JOUR
T1 - Association between sedentary time and cognitive function: A focus on different domains of sedentary behavior
AU - Wanders, Lisa
AU - Bakker, Esmée A.
AU - van Hout, Hein P. J.
AU - Eijsvogels, Thijs M. H.
AU - Hopman, Maria T. E.
AU - Visser, Leonie N. C.
AU - Wouters, Hans
AU - Thijssen, Dick H. J.
N1 - Funding Information: L. Wanders received funding from the Netherlands Organization for Scientific Research [grant number ALWTF.2016.032 ]. COST-A was developed by a grant from the Stoffels Hornstra foundation . The authors declare no competing interests in the writing of this article. The funding sources had no involvement in the study design, the collection, analysis or interpretation of data, nor in the writing of the report or the decision to submit the article for publication. Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Studies which examined the association between sedentary behavior (SB) and cognitive function have presented equivocal findings. Mentally active/inactive sedentary domains may relate differently to cognitive function. We examined associations between SB and cognitive function, specifically focusing on different domains. Participants were recruited from the Nijmegen Exercise Study 2018 in the Netherlands. SB (h/day) was measured with the Sedentary Behavior Questionnaire. Cognitive function was assessed with a validated computer self-test (COST-A), and a z-score calculated for global cognitive function. Multivariate linear regression assessed associations between tertiles of sedentary time and cognitive function. Cognition tests were available from 2821 participants, complete data from 2237 participants (43% female), with a median age of 61 [IQR 52–67] and a mean sedentary time of 8.3 ± 3.2 h/day. In fully adjusted models, cognitive function was significantly better in participants with the highest total sedentary time (0.07 [95% CI 0.02–0.12], P = 0.01), work-related sedentary time (0.13 [95% CI 0.07–0.19], P < 0.001), and non-occupational computer time (0.07 [95% CI 0.02–0.12], P = 0.01), compared to the least sedentary. Leisure sedentary time and time spent sedentary in the domains TV, reading or creative time showed no association with cognitive function in final models (all P > 0.05). We found a strong, independent positive association between total SB and cognitive function in a heterogenous population. This relation was not consistent across different domains, with especially work- and computer-related SB being positively associated with cognitive function. This highlights the importance of assessing the various sedentary domains in understanding the relation between sedentary time and cognitive function.
AB - Studies which examined the association between sedentary behavior (SB) and cognitive function have presented equivocal findings. Mentally active/inactive sedentary domains may relate differently to cognitive function. We examined associations between SB and cognitive function, specifically focusing on different domains. Participants were recruited from the Nijmegen Exercise Study 2018 in the Netherlands. SB (h/day) was measured with the Sedentary Behavior Questionnaire. Cognitive function was assessed with a validated computer self-test (COST-A), and a z-score calculated for global cognitive function. Multivariate linear regression assessed associations between tertiles of sedentary time and cognitive function. Cognition tests were available from 2821 participants, complete data from 2237 participants (43% female), with a median age of 61 [IQR 52–67] and a mean sedentary time of 8.3 ± 3.2 h/day. In fully adjusted models, cognitive function was significantly better in participants with the highest total sedentary time (0.07 [95% CI 0.02–0.12], P = 0.01), work-related sedentary time (0.13 [95% CI 0.07–0.19], P < 0.001), and non-occupational computer time (0.07 [95% CI 0.02–0.12], P = 0.01), compared to the least sedentary. Leisure sedentary time and time spent sedentary in the domains TV, reading or creative time showed no association with cognitive function in final models (all P > 0.05). We found a strong, independent positive association between total SB and cognitive function in a heterogenous population. This relation was not consistent across different domains, with especially work- and computer-related SB being positively associated with cognitive function. This highlights the importance of assessing the various sedentary domains in understanding the relation between sedentary time and cognitive function.
KW - Cognition
KW - Mentally active
KW - Mentally inactive
KW - Sitting
UR - http://www.scopus.com/inward/record.url?scp=85112826250&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ypmed.2021.106731
DO - https://doi.org/10.1016/j.ypmed.2021.106731
M3 - Article
C2 - 34280406
SN - 0091-7435
VL - 153
JO - Preventive medicine
JF - Preventive medicine
M1 - 106731
ER -