TY - JOUR
T1 - Association of beta blocker use and hearing ability in adults: a cross-sectional study
AU - Wung, Deanna
AU - Goderie, Thadé
AU - van Wier, Marieke F.
AU - Stam, Mariska
AU - Kramer, Sophia E.
N1 - Publisher Copyright: © 2021 The Authors. Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of British Society of Audiology, International Society of Audiology, and Nordic Audiological Society. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2022/2
Y1 - 2022/2
N2 - Objectives: To investigate the potential association between beta blocker use and hearing ability in adults and to discern whether this effect is dose-dependent. Design: Cross-sectional analyses. Multiple linear regression was performed with hearing ability as the dependent variable and beta blocker use as the independent variable. The independent variable was classified into three dose categories for secondary analysis. Adjustments were made for age, gender, educational level, and tobacco smoking status. Study sample: 1636 adults, 75 of whom reported being on beta blockers, from the internet-based Netherlands Longitudinal Study on Hearing (NL-SH). Results: No significant association was found between beta blocker use and hearing ability in noise. In the adjusted regressions, beta blocker use changed the speech reception threshold in noise (SRT) by −0.04 dB signal-to-noise ratio (SNR) (95%CI [−0.67 to 0.58], p = 0.890). Medium dose beta blocker use changed SRT by −0.42 dB SNR (95%CI [−1.38 to 0.71], p = 0.433), while a high dose changed it by −0.26 dB SNR (95%CI [−1.74 to 1.4], p = 0.767). Conclusions: No evidence was found for beta blocker-induced changes in hearing ability. Future studies on this topic should favour case-control and cohort study designs, while focussing on a hypertensive population to minimise confounding by indication.
AB - Objectives: To investigate the potential association between beta blocker use and hearing ability in adults and to discern whether this effect is dose-dependent. Design: Cross-sectional analyses. Multiple linear regression was performed with hearing ability as the dependent variable and beta blocker use as the independent variable. The independent variable was classified into three dose categories for secondary analysis. Adjustments were made for age, gender, educational level, and tobacco smoking status. Study sample: 1636 adults, 75 of whom reported being on beta blockers, from the internet-based Netherlands Longitudinal Study on Hearing (NL-SH). Results: No significant association was found between beta blocker use and hearing ability in noise. In the adjusted regressions, beta blocker use changed the speech reception threshold in noise (SRT) by −0.04 dB signal-to-noise ratio (SNR) (95%CI [−0.67 to 0.58], p = 0.890). Medium dose beta blocker use changed SRT by −0.42 dB SNR (95%CI [−1.38 to 0.71], p = 0.433), while a high dose changed it by −0.26 dB SNR (95%CI [−1.74 to 1.4], p = 0.767). Conclusions: No evidence was found for beta blocker-induced changes in hearing ability. Future studies on this topic should favour case-control and cohort study designs, while focussing on a hypertensive population to minimise confounding by indication.
KW - Hearing
KW - adverse effects
KW - beta blockers
KW - medication
KW - ototoxicity
UR - http://www.scopus.com/inward/record.url?scp=85107366792&partnerID=8YFLogxK
U2 - https://doi.org/10.1080/14992027.2021.1915508
DO - https://doi.org/10.1080/14992027.2021.1915508
M3 - Article
C2 - 34057380
SN - 1499-2027
VL - 61
SP - 102
EP - 107
JO - International Journal of Audiology
JF - International Journal of Audiology
IS - 2
ER -