Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection

Maureen P Martin, Michael M Lederman, Holli B Hutcheson, James J Goedert, George W Nelson, Yvette van Kooyk, Roger Detels, Susan Buchbinder, Keith Hoots, David Vlahov, Stephen J O'Brien, Mary Carrington

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12 Citations (Scopus)


There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral (n = 713) or mucosal (n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had -336C were more susceptible to infection than were persons with -336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested.

Original languageEnglish
Pages (from-to)14053-6
Number of pages4
JournalJournal of virology
Issue number24
Publication statusPublished - Dec 2004


  • Cell Adhesion Molecules/genetics
  • Cohort Studies
  • HIV Infections/genetics
  • HIV-1/pathogenicity
  • Humans
  • Infusions, Parenteral
  • Lectins, C-Type/genetics
  • Mucous Membrane
  • Polymorphism, Genetic
  • Promoter Regions, Genetic/genetics
  • Receptors, Cell Surface/genetics

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