TY - JOUR
T1 - Associations between macrovascular and renal microvascular dysfunction in type 2 diabetes and non-diabetes: the HELIUS study
AU - Hayfron-Benjamin, Charles F.
AU - Amoah, Albert G. B.
AU - Maitland - van der Zee, Anke H.
AU - van Charante, Eric Moll
AU - Galenkamp, Henrike
AU - van den Born, Bert-Jan
AU - Agyemang, Charles
N1 - Funding Information: The HELIUS study is conducted by the Amsterdam University Medical Center , location AMC and the Public Health Service of Amsterdam . Both organizations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation (Hartstichting; grant no. 2010T084 ), the Netherlands Organization for Health Research and Development (ZonMw; grant no. 200500003 ), the European Union (Seventh Framework Programme, FP-7; grant no. 278901 ), and the European Fund for the Integration of non-EU immigrants (EIF; grant no. 2013EIF013 ). Publisher Copyright: © 2021 The Authors
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Background: Although the associations between measures of macrovascular and microvascular dysfunctions are well characterized in diabetes, there is limited data on these associations in individuals without diabetes. We compared the associations between macrovascular dysfunction and renal microvascular dysfunction in individuals with type 2 diabetes (T2D) and without diabetes. Methods: Cross-sectional analyses of baseline data from the multiethnic Healthy Life in an Urban Setting (HELIUS) study (Amsterdam, the Netherlands), including 986 participants with T2D and 7680 participants without diabetes were done. Logistic regression analyses were used to examine the associations between macrovascular dysfunction [aortic stiffness, coronary artery disease (CAD), peripheral artery disease (PAD), and stroke] and renal microvascular dysfunction [albuminuria] with adjustments for age, sex, ethnicity, waist-to-hip ratio, systolic blood pressure, LDL-cholesterol, and smoking (and HbA1c and diabetes duration for the T2D group). Results: In the fully adjusted models, aortic stiffness was associated with albuminuria in individuals with T2D [OR 2.55; 95% CI,1.30–4.98], but not without diabetes [0.96; 0.63–1.45]; stroke was associated with albuminuria in T2D [2.40;1.10–5.25], but not in non-diabetes [1.39;0.83–2.33]. In age-sex adjusted models, CAD was associated with albuminuria in T2D [1.65;1.09–2.50] and in non-diabetes [1.56;1.13–2.15]; the associations were no longer significant in the fully adjusted model. There were no associations between PAD and albuminuria in T2D and non-diabetes. Conclusions: Our study shows important differences in the associations between measures of macrovascular and renal microvascular dysfunction in T2D and non-diabetes. These findings provide opportunities for future research aimed at prevention and treatment strategies for individuals with vascular dysfunction.
AB - Background: Although the associations between measures of macrovascular and microvascular dysfunctions are well characterized in diabetes, there is limited data on these associations in individuals without diabetes. We compared the associations between macrovascular dysfunction and renal microvascular dysfunction in individuals with type 2 diabetes (T2D) and without diabetes. Methods: Cross-sectional analyses of baseline data from the multiethnic Healthy Life in an Urban Setting (HELIUS) study (Amsterdam, the Netherlands), including 986 participants with T2D and 7680 participants without diabetes were done. Logistic regression analyses were used to examine the associations between macrovascular dysfunction [aortic stiffness, coronary artery disease (CAD), peripheral artery disease (PAD), and stroke] and renal microvascular dysfunction [albuminuria] with adjustments for age, sex, ethnicity, waist-to-hip ratio, systolic blood pressure, LDL-cholesterol, and smoking (and HbA1c and diabetes duration for the T2D group). Results: In the fully adjusted models, aortic stiffness was associated with albuminuria in individuals with T2D [OR 2.55; 95% CI,1.30–4.98], but not without diabetes [0.96; 0.63–1.45]; stroke was associated with albuminuria in T2D [2.40;1.10–5.25], but not in non-diabetes [1.39;0.83–2.33]. In age-sex adjusted models, CAD was associated with albuminuria in T2D [1.65;1.09–2.50] and in non-diabetes [1.56;1.13–2.15]; the associations were no longer significant in the fully adjusted model. There were no associations between PAD and albuminuria in T2D and non-diabetes. Conclusions: Our study shows important differences in the associations between measures of macrovascular and renal microvascular dysfunction in T2D and non-diabetes. These findings provide opportunities for future research aimed at prevention and treatment strategies for individuals with vascular dysfunction.
KW - Albuminuria
KW - Aortic stiffness
KW - Cardiovascular disease
KW - Coronary artery disease
KW - Macrovascular dysfunction
KW - Microvascular dysfunction
KW - Peripheral artery disease
KW - Stroke
KW - The HELIUS study
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85102872357&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.mvr.2021.104162
DO - https://doi.org/10.1016/j.mvr.2021.104162
M3 - Article
C2 - 33705823
SN - 0026-2862
VL - 136
JO - Microvascular Research
JF - Microvascular Research
M1 - 104162
ER -