TY - JOUR
T1 - Associations Between Symptoms, Donor Characteristics and IgG Antibody Response in 2082 COVID-19 Convalescent Plasma Donors
AU - Vinkenoog, Marieke
AU - Steenhuis, Maurice
AU - Brinke, Anja Ten
AU - van Hasselt, J. G. Coen
AU - Janssen, Mart P.
AU - van Leeuwen, Matthijs
AU - Swaneveld, Francis H.
AU - Vrielink, Hans
AU - van de Watering, Leo
AU - Quee, Franke
AU - van den Hurk, Katja
AU - Rispens, Theo
AU - Hogema, Boris
AU - van der Schoot, C. Ellen
N1 - Funding Information: This study was supported by the European Commission (SUPPORT-E, grant number 101015756), by ZonMW (Protective Immunity, grant number 10430 01 201 0012), and Sanquin Blood Supply Foundation, PPOC grant 18-14/L2337. Publisher Copyright: © 2022 Vinkenoog, Steenhuis, Brinke, van Hasselt, Janssen, van Leeuwen, Swaneveld, Vrielink, van de Watering, Quee, van den Hurk, Rispens, Hogema and van der Schoot. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
PY - 2022
Y1 - 2022
N2 - Many studies already reported on the association between patient characteristics on the severity of COVID-19 disease outcome, but the relation with SARS-CoV-2 antibody levels is less clear. To investigate this in more detail, we performed a retrospective observational study in which we used the IgG antibody response from 11,118 longitudinal antibody measurements of 2,082 unique COVID convalescent plasma donors. COVID-19 symptoms and donor characteristics were obtained by a questionnaire. Antibody responses were modelled using a linear mixed-effects model. Our study confirms that the SARS-CoV-2 antibody response is associated with patient characteristics like body mass index and age. Antibody decay was faster in male than in female donors (average half-life of 62 versus 72 days). Most interestingly, we also found that three symptoms (headache, anosmia, nasal cold) were associated with lower peak IgG, while six other symptoms (dry cough, fatigue, diarrhoea, fever, dyspnoea, muscle weakness) were associated with higher IgG concentrations.
AB - Many studies already reported on the association between patient characteristics on the severity of COVID-19 disease outcome, but the relation with SARS-CoV-2 antibody levels is less clear. To investigate this in more detail, we performed a retrospective observational study in which we used the IgG antibody response from 11,118 longitudinal antibody measurements of 2,082 unique COVID convalescent plasma donors. COVID-19 symptoms and donor characteristics were obtained by a questionnaire. Antibody responses were modelled using a linear mixed-effects model. Our study confirms that the SARS-CoV-2 antibody response is associated with patient characteristics like body mass index and age. Antibody decay was faster in male than in female donors (average half-life of 62 versus 72 days). Most interestingly, we also found that three symptoms (headache, anosmia, nasal cold) were associated with lower peak IgG, while six other symptoms (dry cough, fatigue, diarrhoea, fever, dyspnoea, muscle weakness) were associated with higher IgG concentrations.
KW - CCP
KW - COVID-19
KW - antibodies
KW - longitudinal
KW - symptoms
UR - http://www.scopus.com/inward/record.url?scp=85126659276&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/fimmu.2022.821721
DO - https://doi.org/10.3389/fimmu.2022.821721
M3 - Article
C2 - 35296077
VL - 13
SP - 821721
JO - Frontiers in Immunology: Molecular Innate Immunity
JF - Frontiers in Immunology: Molecular Innate Immunity
SN - 1664-3224
M1 - 821721
ER -