TY - JOUR
T1 - Associations of psychosocial stress with type 2 diabetes and glycaemic control among Ghanaians
T2 - The RODAM study
AU - Chilunga, Felix P.
AU - Schwerzel, Pleun S.
AU - Meeks, Karlijn A. C.
AU - Beune, Erik
AU - Bahendeka, Silver
AU - Mockenhaupt, Frank
AU - Klipstein-Grobusch, Kerstin
AU - Agyemang, Charles
N1 - Funding Information: This work was supported by the European Commission under the Framework Programme (Grant Number: 278901) and European Research Council Consolidation (Grant Number: 772244). Publisher Copyright: © 2022 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK.
PY - 2023/1
Y1 - 2023/1
N2 - Background: The extent to which psychosocial stress relates to type 2 diabetes among sub-Saharan Africans is not well understood. We assessed associations of psychosocial stresses with type 2 diabetes status and glycaemic control among Ghanaians. Methods: We used data from Research on Obesity and Diabetes among African Migrants (RODAM) study. We performed logistic and linear regression models to assess association of psychosocial stresses with type 2 diabetes and HbA1c respectively with adjustments for age, sex, education and other stresses. We also assessed moderation effects of migration status (migrant Ghanaians vs. non-migrant Ghanaians), age, sex and education by adding interaction terms in models. Results: Four thousand eight hundred and forty one Ghanaians were included with 44% resident in Ghana, 62% women, mean age of 46 years and 10% having type 2 diabetes. Psychosocial stress at home and at work were not associated with type 2 diabetes or HbA1c levels. Negative life events in past 12 months were negatively associated with type 2 diabetes (adjusted odds ratio = 0.93, 95% CI 0.87–0.99). Perceived discrimination was positively associated with type 2 diabetes (aOR = 1.01, 95% CI 1.004–1.03). Both associations were more pronounced in men. Perceived discrimination was also positively associated with HbA1c levels, especially among those with type 2 diabetes (adjusted β = 0.01, 95% CI 0.007–0.02). Conclusions: Perceived discrimination and negative life events are associated with type 2 diabetes and glycaemic control among Ghanaians, especially in men. Further studies are needed to identify context-specific mechanisms underlying these associations.
AB - Background: The extent to which psychosocial stress relates to type 2 diabetes among sub-Saharan Africans is not well understood. We assessed associations of psychosocial stresses with type 2 diabetes status and glycaemic control among Ghanaians. Methods: We used data from Research on Obesity and Diabetes among African Migrants (RODAM) study. We performed logistic and linear regression models to assess association of psychosocial stresses with type 2 diabetes and HbA1c respectively with adjustments for age, sex, education and other stresses. We also assessed moderation effects of migration status (migrant Ghanaians vs. non-migrant Ghanaians), age, sex and education by adding interaction terms in models. Results: Four thousand eight hundred and forty one Ghanaians were included with 44% resident in Ghana, 62% women, mean age of 46 years and 10% having type 2 diabetes. Psychosocial stress at home and at work were not associated with type 2 diabetes or HbA1c levels. Negative life events in past 12 months were negatively associated with type 2 diabetes (adjusted odds ratio = 0.93, 95% CI 0.87–0.99). Perceived discrimination was positively associated with type 2 diabetes (aOR = 1.01, 95% CI 1.004–1.03). Both associations were more pronounced in men. Perceived discrimination was also positively associated with HbA1c levels, especially among those with type 2 diabetes (adjusted β = 0.01, 95% CI 0.007–0.02). Conclusions: Perceived discrimination and negative life events are associated with type 2 diabetes and glycaemic control among Ghanaians, especially in men. Further studies are needed to identify context-specific mechanisms underlying these associations.
KW - glycaemic control
KW - psychosocial stress
KW - sub-Saharan Africans; migration
KW - type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85142273514&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/dme.15006
DO - https://doi.org/10.1111/dme.15006
M3 - Article
C2 - 36373887
SN - 0742-3071
VL - 40
JO - Diabetic medicine
JF - Diabetic medicine
IS - 1
M1 - e15006
ER -