TY - JOUR
T1 - Ataxia with vitamin E deficiency
T2 - Biochemical effects of malcompliance with vitamin E therapy
AU - Schuelke, M.
AU - Finckh, B.
AU - Sistermans, E. A.
AU - Ausems, M. G.E.M.
AU - Hübner, C.
AU - Von Moers, A.
AU - Murphy, Peregrine L.
PY - 2000/11/28
Y1 - 2000/11/28
N2 - To prevent neuronal damage, patients with ataxia with isolated vitamin E deficiency need lifelong supplementation with high doses of vitamin E. Short interruptions of therapy, such as occur in malcompliance, do not lead to clinical symptoms. However, the authors show that even short withdrawals may cause a prolonged decrease of the total radical trapping capacity of plasma; its major contributors, such as urate and sulfhydryl groups, fail to compensate for the missing vitamin E.
AB - To prevent neuronal damage, patients with ataxia with isolated vitamin E deficiency need lifelong supplementation with high doses of vitamin E. Short interruptions of therapy, such as occur in malcompliance, do not lead to clinical symptoms. However, the authors show that even short withdrawals may cause a prolonged decrease of the total radical trapping capacity of plasma; its major contributors, such as urate and sulfhydryl groups, fail to compensate for the missing vitamin E.
UR - http://www.scopus.com/inward/record.url?scp=0034727631&partnerID=8YFLogxK
U2 - https://doi.org/10.1212/WNL.55.10.1584
DO - https://doi.org/10.1212/WNL.55.10.1584
M3 - Article
C2 - 11094124
SN - 0028-3878
VL - 55
SP - 1584
EP - 1586
JO - Neurology
JF - Neurology
IS - 10
ER -