TY - JOUR
T1 - AVIATOR: An open international registry to evaluate medical and surgical outcomes of aortic valve insufficiency and ascending aorta aneurysm
AU - Aortic Valve Repair Research Network Investigators
AU - de Heer, Frederiek
AU - Kluin, Jolanda
AU - Elkhoury, Gebrine
AU - Jondeau, Guillaume
AU - Enriquez-Sarano, Maurice
AU - Schäfers, Hans-Joachim
AU - Takkenberg, Johanna J. M.
AU - Lansac, Emmanuel
AU - Dinges, Christian
AU - Steindl, Johannes
AU - Ziller, Rosina
AU - de Kerchove, Laurent
AU - Benkacem, Taoufik
AU - Coulon, Corinne
AU - Kaddouri, Fadoua
AU - Vanoverschelde, Jean-Louis
AU - de Meester, Christophe
AU - Pasquet, Agnès
AU - Nijs, Jan
AU - van Mosselvelde, Veerle
AU - Loeys, Bart
AU - Meuris, Bart
AU - Schepmans, Evi
AU - van den Bossche, Klaartje
AU - Verbrugghe, Peter
AU - Goossens, Wenke
AU - Gutermann, Herbert
AU - Pettinari, Matteo
AU - el-Hamamsy, Ismail
AU - Lenoir, Marien
AU - Noly, Pierre-Emmanuel
AU - Tousch, Michael
AU - Shah, Pallav
AU - Boodhwani, Munir
AU - Rudez, Igor
AU - Baric, Davor
AU - Unic, Daniel
AU - Varvodic, Josip
AU - Gjorgijevska, Savica
AU - Vojacek, Jan
AU - Zacek, Pavel
AU - Karalko, Mikita
AU - Hlubocky, Jaroslav
AU - Novotny, Robert
AU - Slautin, Andrey
AU - Soliman, Said
AU - Arnaud-Crozat, Eric
AU - Boignard, Aude
AU - Fayad, Georges
AU - Koolbergen, Dave
PY - 2019/6
Y1 - 2019/6
N2 - Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included. Methods: The AV repair research network includes surgeons, cardiologists, and scientists and established an online database compliant with the guidelines for reporting valve-related events. Prospective inclusion started from January 2013. Adult patients (18 years or older) who were operated on between 1995 and 2017 with complete procedural specification of the type of repair/replacement were selected for descriptive analysis. Results: Currently 58 centers from 17 countries include 4896 patients with 89% AV repair (n = 4379) versus 11% AV replacement (n = 517). AV repair was either isolated (28%), or associated with tubular/partial root replacement (22%) or valve-sparing root replacement (49%) with an in-hospital mortality of 0.5%, 1.7%, and 1.2%, respectively. AV replacement was either isolated (24%), associated with tubular/partial root replacement (17%) or root replacement (59%) with an in-hospital mortality of 1%, 2.6%, and 2.0%, respectively. Conclusions: The multicenter surgical AVIATOR registry, by applying uniform definitions, should provide a solid evidence base to evaluate the place of repair versus replacement on the basis of long-term patient outcomes. Obtaining data completeness and adequate representation of all surgery types remain challenging. Toward the near future AVIATOR-medical will start to study natural history, as will AVIATOR-kids, with a focus on pediatric disease.
AB - Objectives: Current national registries are lacking detailed pathology-driven analysis and long-term patients outcomes. The Heart Valve Society (HVS) aortic valve (AV) repair research network started the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) to evaluate long-term patient outcomes of AV repair and replacement. The purpose of the current report is to describe the AVIATOR initiative and report in a descriptive manner the patients included. Methods: The AV repair research network includes surgeons, cardiologists, and scientists and established an online database compliant with the guidelines for reporting valve-related events. Prospective inclusion started from January 2013. Adult patients (18 years or older) who were operated on between 1995 and 2017 with complete procedural specification of the type of repair/replacement were selected for descriptive analysis. Results: Currently 58 centers from 17 countries include 4896 patients with 89% AV repair (n = 4379) versus 11% AV replacement (n = 517). AV repair was either isolated (28%), or associated with tubular/partial root replacement (22%) or valve-sparing root replacement (49%) with an in-hospital mortality of 0.5%, 1.7%, and 1.2%, respectively. AV replacement was either isolated (24%), associated with tubular/partial root replacement (17%) or root replacement (59%) with an in-hospital mortality of 1%, 2.6%, and 2.0%, respectively. Conclusions: The multicenter surgical AVIATOR registry, by applying uniform definitions, should provide a solid evidence base to evaluate the place of repair versus replacement on the basis of long-term patient outcomes. Obtaining data completeness and adequate representation of all surgery types remain challenging. Toward the near future AVIATOR-medical will start to study natural history, as will AVIATOR-kids, with a focus on pediatric disease.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058193656&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30553597
U2 - https://doi.org/10.1016/j.jtcvs.2018.10.076
DO - https://doi.org/10.1016/j.jtcvs.2018.10.076
M3 - Article
C2 - 30553597
SN - 0022-5223
VL - 157
SP - 2202-2211.e7
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
IS - 6
ER -