Azole-Resistant Central Nervous System Aspergillosis

Jan W. M. van der Linden; Rogier R. Jansen; Dorine Bresters; Caroline E. Visser; Suzanne E. Geerlings; Ed J. Kuijper; Willem J. G. Melchers; Paul E. Verweij

doi:https://doi.org/10.1086/597465

Azole-Resistant Central Nervous System Aspergillosis

Jan W. M. van der Linden, Rogier R. Jansen, Dorine Bresters, Caroline E. Visser, Suzanne E. Geerlings, Ed J. Kuijper, Willem J. G. Melchers, Paul E. Verweij

Research output: Contribution to journal › Editorial › Academic › peer-review

78 Citations (Scopus)

Abstract

Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34-base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy or with polyenes, but all patients died. Azole resistance significantly complicates the management of aspergillosis by delaying the initiation of adequate therapy and because effective alternative antifungal drugs are lacking

Original language	English
Pages (from-to)	1111-1113
Journal	Clinical Infectious Diseases
Volume	48
Issue number	8
DOIs	https://doi.org/10.1086/597465
Publication status	Published - 2009

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https://doi.org/10.1086/597465

Cite this

@article{84f99cf855f84606ae067fe45d792195,

title = "Azole-Resistant Central Nervous System Aspergillosis",

abstract = "Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34-base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy or with polyenes, but all patients died. Azole resistance significantly complicates the management of aspergillosis by delaying the initiation of adequate therapy and because effective alternative antifungal drugs are lacking",

author = "{van der Linden}, {Jan W. M.} and Jansen, {Rogier R.} and Dorine Bresters and Visser, {Caroline E.} and Geerlings, {Suzanne E.} and Kuijper, {Ed J.} and Melchers, {Willem J. G.} and Verweij, {Paul E.}",

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AU - van der Linden, Jan W. M.

AU - Jansen, Rogier R.

AU - Bresters, Dorine

AU - Visser, Caroline E.

AU - Geerlings, Suzanne E.

AU - Kuijper, Ed J.

AU - Melchers, Willem J. G.

AU - Verweij, Paul E.

PY - 2009

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N2 - Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34-base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy or with polyenes, but all patients died. Azole resistance significantly complicates the management of aspergillosis by delaying the initiation of adequate therapy and because effective alternative antifungal drugs are lacking

AB - Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34-base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy or with polyenes, but all patients died. Azole resistance significantly complicates the management of aspergillosis by delaying the initiation of adequate therapy and because effective alternative antifungal drugs are lacking

U2 - https://doi.org/10.1086/597465

DO - https://doi.org/10.1086/597465

M3 - Editorial

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JO - Clinical Infectious Diseases

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