TY - JOUR
T1 - B/A Measurement of Clear Cell Renal Cell Carcinoma versus Healthy Kidney Tissue
AU - Panfilova, Anastasiia
AU - Chen, Xufei
AU - Widdershoven, Christiaan
AU - Freund, Jan Erik
AU - Heijink, Dilara Savci
AU - Zondervan, Patricia
AU - van Sloun, Ruud J. G.
AU - Sapozhnikov, Oleg A.
AU - Wijkstra, Hessel
AU - Mischi, Massimo
N1 - Funding Information: This research was supported by the Eindhoven MedTech Innovation Center and in part by the Russian Science Foundation under Grant No. 19-12-00148 (O.A.S.). Publisher Copyright: © 2022 The Authors
PY - 2022/7
Y1 - 2022/7
N2 - The acoustic parameter of non-linearity B/A has been found capable of discriminating some types of pathological tissue from healthy tissue. The literature on the utility of B/A for cancer diagnostics is very limited, with measurements on the human breast and liver. This work expands the current research on cancer diagnostics by B/A assessment of eight slices of human clear cell renal cell carcinoma (ccRCC) from two patients and four slices of healthy kidney tissue from two healthy kidney samples. The Wilcoxon test identified the B/A distribution of malignant tissue as not significantly different from that of healthy tissue. An alternative way of defining outliers resulted in median B/A values of 8.1 for ccRCC and 6.8 for healthy tissue (p < 0.05). Acoustic attenuation at 2.1 MHz was significantly greater (p < 0.05) for ccRCC (1.7 dB/cm) than for healthy tissue (1.0 dB/cm). The observed differences in the measured values suggest that B/A and acoustic attenuation may represent potential diagnostic markers of ccRCC. More data and an improved experimental design are required to provide a definitive conclusion on the utility of B/A for cancer diagnostics.
AB - The acoustic parameter of non-linearity B/A has been found capable of discriminating some types of pathological tissue from healthy tissue. The literature on the utility of B/A for cancer diagnostics is very limited, with measurements on the human breast and liver. This work expands the current research on cancer diagnostics by B/A assessment of eight slices of human clear cell renal cell carcinoma (ccRCC) from two patients and four slices of healthy kidney tissue from two healthy kidney samples. The Wilcoxon test identified the B/A distribution of malignant tissue as not significantly different from that of healthy tissue. An alternative way of defining outliers resulted in median B/A values of 8.1 for ccRCC and 6.8 for healthy tissue (p < 0.05). Acoustic attenuation at 2.1 MHz was significantly greater (p < 0.05) for ccRCC (1.7 dB/cm) than for healthy tissue (1.0 dB/cm). The observed differences in the measured values suggest that B/A and acoustic attenuation may represent potential diagnostic markers of ccRCC. More data and an improved experimental design are required to provide a definitive conclusion on the utility of B/A for cancer diagnostics.
KW - B/A measurement
KW - Cancer diagnostics
KW - Non-linear parameter B/A
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85127833439&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ultrasmedbio.2022.02.024
DO - https://doi.org/10.1016/j.ultrasmedbio.2022.02.024
M3 - Article
C2 - 35414449
SN - 0301-5629
VL - 48
SP - 1348
EP - 1355
JO - Ultrasound in medicine & biology
JF - Ultrasound in medicine & biology
IS - 7
ER -