Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes

S. Youn; L. J. Phillips; G. P. Amminger; G. Berger; E. Y. H. Chen; L. de Haan; J. A. Hartmann; I. B. Hickie; S. Lavoie; C. Markulev; P. D. McGorry; N. Mossaheb; D. H. Nieman; M. Nordentoft; A. Riecher-Rössler; M. R. Schäfer; M. Schlögelhofer; S. Smesny; A. Thompson; S. Verma; H. P. Yuen; A. R. Yung; B. Nelson

doi:https://doi.org/10.1016/j.schres.2019.11.047

Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes

S. Youn, L. J. Phillips, G. P. Amminger, G. Berger, E. Y. H. Chen, L. de Haan, J. A. Hartmann, I. B. Hickie, S. Lavoie, C. Markulev, P. D. McGorry, N. Mossaheb, D. H. Nieman, M. Nordentoft, A. Riecher-Rössler, M. R. Schäfer, M. Schlögelhofer, S. Smesny, A. Thompson, S. VermaH. P. Yuen, A. R. Yung, B. Nelson

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Abstract

There has been limited research into the predictive value of basic symptoms and their relationship with other psychopathology in patients identified using the ‘ultra high risk’ (UHR) for psychosis approach. The current study investigated whether basic symptoms, specifically cognitive disturbances (COGDIS), were associated with a greater risk of transition to psychotic disorder and persistent attenuated psychotic symptoms (APS) at medium term follow-up (mean = 3.4 years) in UHR patients, as well as with general psychopathology at baseline. The sample included 304 UHR participants (mean age = 19.12 years) involved in an international multicenter trial of omega-3 fatty acids. UHR individuals who also met the COGDIS criteria (basic symptoms risk criteria) did not have a greater risk of transition than those who met the UHR criteria alone. However, meeting COGDIS risk criteria was associated with a greater likelihood of meeting the UHR attenuated psychotic symptoms risk group (i.e., having persistent attenuated psychotic symptoms) at 12-month follow-up (odds ratio = 1.85; 95% CI = 1.03, 3.32). Greater severity of cognitive basic symptoms was also independently associated with more severe general psychopathology at study entry. The findings do not support the notion that combined risk identification approaches (UHR and basic symptoms) aid in the identification of individuals at greatest risk of psychosis, although this interpretation is limited by the modest transition to psychosis rate (13%) and the time of follow up. However, the findings indicate that basic symptoms may be a clinically useful marker of more severe general psychopathology in UHR groups and risk for persistent attenuated psychotic symptoms.

Original language	English
Pages (from-to)	255-261
Number of pages	7
Journal	Schizophrenia Research
Volume	216
DOIs	https://doi.org/10.1016/j.schres.2019.11.047
Publication status	Published - Feb 2020

Keywords

Basic symptoms
Prodrome
Psychopathology
Psychosis
Risk factors

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https://doi.org/10.1016/j.schres.2019.11.047

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Youn, S., Phillips, L. J., Amminger, G. P., Berger, G., Chen, E. Y. H., de Haan, L., Hartmann, J. A., Hickie, I. B., Lavoie, S., Markulev, C., McGorry, P. D., Mossaheb, N., Nieman, D. H., Nordentoft, M., Riecher-Rössler, A., Schäfer, M. R., Schlögelhofer, M., Smesny, S., Thompson, A., ... Nelson, B. (2020). Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes. Schizophrenia Research, 216, 255-261. https://doi.org/10.1016/j.schres.2019.11.047

@article{9021ea671e934ae6a380863a6fe385cc,

title = "Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes",

abstract = "There has been limited research into the predictive value of basic symptoms and their relationship with other psychopathology in patients identified using the {\textquoteleft}ultra high risk{\textquoteright} (UHR) for psychosis approach. The current study investigated whether basic symptoms, specifically cognitive disturbances (COGDIS), were associated with a greater risk of transition to psychotic disorder and persistent attenuated psychotic symptoms (APS) at medium term follow-up (mean = 3.4 years) in UHR patients, as well as with general psychopathology at baseline. The sample included 304 UHR participants (mean age = 19.12 years) involved in an international multicenter trial of omega-3 fatty acids. UHR individuals who also met the COGDIS criteria (basic symptoms risk criteria) did not have a greater risk of transition than those who met the UHR criteria alone. However, meeting COGDIS risk criteria was associated with a greater likelihood of meeting the UHR attenuated psychotic symptoms risk group (i.e., having persistent attenuated psychotic symptoms) at 12-month follow-up (odds ratio = 1.85; 95% CI = 1.03, 3.32). Greater severity of cognitive basic symptoms was also independently associated with more severe general psychopathology at study entry. The findings do not support the notion that combined risk identification approaches (UHR and basic symptoms) aid in the identification of individuals at greatest risk of psychosis, although this interpretation is limited by the modest transition to psychosis rate (13%) and the time of follow up. However, the findings indicate that basic symptoms may be a clinically useful marker of more severe general psychopathology in UHR groups and risk for persistent attenuated psychotic symptoms.",

keywords = "Basic symptoms, Prodrome, Psychopathology, Psychosis, Risk factors",

author = "S. Youn and Phillips, {L. J.} and Amminger, {G. P.} and G. Berger and Chen, {E. Y. H.} and {de Haan}, L. and Hartmann, {J. A.} and Hickie, {I. B.} and S. Lavoie and C. Markulev and McGorry, {P. D.} and N. Mossaheb and Nieman, {D. H.} and M. Nordentoft and A. Riecher-R{\"o}ssler and Sch{\"a}fer, {M. R.} and M. Schl{\"o}gelhofer and S. Smesny and A. Thompson and S. Verma and Yuen, {H. P.} and Yung, {A. R.} and B. Nelson",

year = "2020",

month = feb,

doi = "https://doi.org/10.1016/j.schres.2019.11.047",

language = "English",

volume = "216",

pages = "255--261",

journal = "Schizophrenia Research",

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Youn, S, Phillips, LJ, Amminger, GP, Berger, G, Chen, EYH, de Haan, L, Hartmann, JA, Hickie, IB, Lavoie, S, Markulev, C, McGorry, PD, Mossaheb, N, Nieman, DH, Nordentoft, M, Riecher-Rössler, A, Schäfer, MR, Schlögelhofer, M, Smesny, S, Thompson, A, Verma, S, Yuen, HP, Yung, AR & Nelson, B 2020, 'Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes', Schizophrenia Research, vol. 216, pp. 255-261. https://doi.org/10.1016/j.schres.2019.11.047

TY - JOUR

T1 - Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes

AU - Youn, S.

AU - Phillips, L. J.

AU - Amminger, G. P.

AU - Berger, G.

AU - Chen, E. Y. H.

AU - de Haan, L.

AU - Hartmann, J. A.

AU - Hickie, I. B.

AU - Lavoie, S.

AU - Markulev, C.

AU - McGorry, P. D.

AU - Mossaheb, N.

AU - Nieman, D. H.

AU - Nordentoft, M.

AU - Riecher-Rössler, A.

AU - Schäfer, M. R.

AU - Schlögelhofer, M.

AU - Smesny, S.

AU - Thompson, A.

AU - Verma, S.

AU - Yuen, H. P.

AU - Yung, A. R.

AU - Nelson, B.

PY - 2020/2

Y1 - 2020/2

N2 - There has been limited research into the predictive value of basic symptoms and their relationship with other psychopathology in patients identified using the ‘ultra high risk’ (UHR) for psychosis approach. The current study investigated whether basic symptoms, specifically cognitive disturbances (COGDIS), were associated with a greater risk of transition to psychotic disorder and persistent attenuated psychotic symptoms (APS) at medium term follow-up (mean = 3.4 years) in UHR patients, as well as with general psychopathology at baseline. The sample included 304 UHR participants (mean age = 19.12 years) involved in an international multicenter trial of omega-3 fatty acids. UHR individuals who also met the COGDIS criteria (basic symptoms risk criteria) did not have a greater risk of transition than those who met the UHR criteria alone. However, meeting COGDIS risk criteria was associated with a greater likelihood of meeting the UHR attenuated psychotic symptoms risk group (i.e., having persistent attenuated psychotic symptoms) at 12-month follow-up (odds ratio = 1.85; 95% CI = 1.03, 3.32). Greater severity of cognitive basic symptoms was also independently associated with more severe general psychopathology at study entry. The findings do not support the notion that combined risk identification approaches (UHR and basic symptoms) aid in the identification of individuals at greatest risk of psychosis, although this interpretation is limited by the modest transition to psychosis rate (13%) and the time of follow up. However, the findings indicate that basic symptoms may be a clinically useful marker of more severe general psychopathology in UHR groups and risk for persistent attenuated psychotic symptoms.

AB - There has been limited research into the predictive value of basic symptoms and their relationship with other psychopathology in patients identified using the ‘ultra high risk’ (UHR) for psychosis approach. The current study investigated whether basic symptoms, specifically cognitive disturbances (COGDIS), were associated with a greater risk of transition to psychotic disorder and persistent attenuated psychotic symptoms (APS) at medium term follow-up (mean = 3.4 years) in UHR patients, as well as with general psychopathology at baseline. The sample included 304 UHR participants (mean age = 19.12 years) involved in an international multicenter trial of omega-3 fatty acids. UHR individuals who also met the COGDIS criteria (basic symptoms risk criteria) did not have a greater risk of transition than those who met the UHR criteria alone. However, meeting COGDIS risk criteria was associated with a greater likelihood of meeting the UHR attenuated psychotic symptoms risk group (i.e., having persistent attenuated psychotic symptoms) at 12-month follow-up (odds ratio = 1.85; 95% CI = 1.03, 3.32). Greater severity of cognitive basic symptoms was also independently associated with more severe general psychopathology at study entry. The findings do not support the notion that combined risk identification approaches (UHR and basic symptoms) aid in the identification of individuals at greatest risk of psychosis, although this interpretation is limited by the modest transition to psychosis rate (13%) and the time of follow up. However, the findings indicate that basic symptoms may be a clinically useful marker of more severe general psychopathology in UHR groups and risk for persistent attenuated psychotic symptoms.

KW - Basic symptoms

KW - Prodrome

KW - Psychopathology

KW - Psychosis

KW - Risk factors

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DO - https://doi.org/10.1016/j.schres.2019.11.047

M3 - Article

C2 - 31866077

SN - 0920-9964

VL - 216

SP - 255

EP - 261

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -

Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes

Abstract

Keywords

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