TY - JOUR
T1 - Bioelectrical impedance analysis and mid-upper arm muscle circumference can be used to detect low muscle mass in clinical practice
AU - Gort-van Dijk, Dorienke
AU - Weerink, Linda B. M.
AU - Milovanovic, Milos
AU - Haveman, Jan-Willem
AU - Hemmer, Patrick H. J.
AU - Dijkstra, Gerard
AU - Lindeboom, Robert
AU - Campmans-Kuijpers, Marjo J. E.
N1 - Funding Information: No funding was required for the conduction of this study. The original data from the SPOT study was funded by Baxter Grant no GHOL6687 and from the SMal-Hipec study by the BBraun Grant no HC-IO-H-1707. Additionally, the use of the equipment was sponsored by Frese-nius Kabi and BBraun. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Identification of low muscle mass becomes increasingly relevant due to its prognostic value in cancer patients. In clinical practice, mid-upper arm muscle circumference (MAMC) and bioelectrical impedance analysis (BIA) are often used to assess muscle mass. For muscle-mass as-sessment, computed tomography (CT) is considered as reference standard. We investigated concordance between CT, BIA, and MAMC, diagnostic accuracy of MAMC, and BIA to detect low muscle mass and their relation with the clinical outcome malnutrition provided with the Patient-Gener-ated Subjective Global Assessment Short Form (PG-SGA SF). This cross-sectional study included adult patients with advanced esophageal and gastrointestinal cancer. BIA, MAMC, and PG-SGA-SF were performed. Routine CT-scans were used to quantify psoas muscle index (PMI) and skeletal muscle area. Good concordance was found between CTPMI and both BIAFFMI (fat free mass index) (ICC 0.73), and BIAASMI (appendicular skeletal muscle index) (ICC 0.69) but not with MAMC (ICC 0.37). BIAFFMI (94%), BIAASMI (86%), and MAMC (86%) showed high specificity but low sensitivity. PG-SGA-SF modestly corre-lated with all muscle-mass measures (ranging from −0.17 to −0.43). Of all patients with low muscle mass, 62% were also classified with a PG-SGA-SF score of ≥ 4 points. Although CT remains the first choice, since both BIA and MAMC are easy to perform by dieticians, they have the potential to be used to detect low muscle mass in clinical practice.
AB - Identification of low muscle mass becomes increasingly relevant due to its prognostic value in cancer patients. In clinical practice, mid-upper arm muscle circumference (MAMC) and bioelectrical impedance analysis (BIA) are often used to assess muscle mass. For muscle-mass as-sessment, computed tomography (CT) is considered as reference standard. We investigated concordance between CT, BIA, and MAMC, diagnostic accuracy of MAMC, and BIA to detect low muscle mass and their relation with the clinical outcome malnutrition provided with the Patient-Gener-ated Subjective Global Assessment Short Form (PG-SGA SF). This cross-sectional study included adult patients with advanced esophageal and gastrointestinal cancer. BIA, MAMC, and PG-SGA-SF were performed. Routine CT-scans were used to quantify psoas muscle index (PMI) and skeletal muscle area. Good concordance was found between CTPMI and both BIAFFMI (fat free mass index) (ICC 0.73), and BIAASMI (appendicular skeletal muscle index) (ICC 0.69) but not with MAMC (ICC 0.37). BIAFFMI (94%), BIAASMI (86%), and MAMC (86%) showed high specificity but low sensitivity. PG-SGA-SF modestly corre-lated with all muscle-mass measures (ranging from −0.17 to −0.43). Of all patients with low muscle mass, 62% were also classified with a PG-SGA-SF score of ≥ 4 points. Although CT remains the first choice, since both BIA and MAMC are easy to perform by dieticians, they have the potential to be used to detect low muscle mass in clinical practice.
KW - Advanced cancer
KW - Anthropometry
KW - Bioelectrical impedance analysis
KW - Body composition
KW - Computed tomography
KW - Mid-upper arm muscle circumference
KW - Muscle mass
KW - Patient generated-subjective global assessment short form
KW - Sarcopenia
UR - http://www.scopus.com/inward/record.url?scp=85109342929&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/nu13072350
DO - https://doi.org/10.3390/nu13072350
M3 - Article
C2 - 34371860
SN - 2072-6643
VL - 13
JO - NUTRIENTS
JF - NUTRIENTS
IS - 7
M1 - 2350
ER -