Biologic implications of genetic changes in head and neck squamous cell carcinogenesis

Colin B.A. Reid, Gordon B. Snow, Ruud H. Brakenhoff, J. N. Boudewi, J. M. Braakhuis

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Abstract

Cytogenetic techniques for the analysis of genelic changes common in head and neck squamous cell carcinogenesis show complex patterns of chromosomal deletions, translocations, and amplifications. Powerful molecular biologic techniques have recently made possible the investigation of these abnormalities at the DNA level. Tumour suppressor gene loss and oncogene activation can now be recognized in tumours. Multiple genetic loci are implicated in the carcinogenesis process, while much evidence points to the existence of yet to be recognized turnout suppressor genes. An overview of the genetic changes commonly seen in head and neck squamous cell carcinogenesis and the possible implications of these are presented.

Original languageEnglish
Pages (from-to)410-416
Number of pages7
JournalAustralian and New Zealand Journal of Surgery
Volume67
Issue number7
DOIs
Publication statusPublished - 1997

Keywords

  • Carcinogenesis
  • Genetic changes
  • Head and neck
  • Squamous cell carcinoma
  • Tumour suppressor genes

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