TY - JOUR
T1 - Biological pathways and genetic mechanisms involved in social functioning
AU - Ordoñana, Juan R.
AU - Bartels, Meike
AU - Boomsma, Dorret I.
AU - Cella, David
AU - Mosing, Miriam
AU - Oliveira, Joao R.
AU - Patrick, Donald L.
AU - Veenhoven, Ruut
AU - Wagner, Gert G.
AU - Sprangers, Mirjam A. G.
AU - AUTHOR GROUP
AU - Abernethy, Amy P.
AU - Baas, Frank
AU - Barsevick, Andrea M.
AU - Bottomley, Andrew
AU - Brundage, Michael
AU - Chauhan, Cynthia
AU - Cleeland, Charles S.
AU - Coens, Corneel
AU - Dueck, Amylou C.
AU - Frost, Marlene H.
AU - Hall, Per
AU - Halyard, Michele Y.
AU - Klepstad, Pål
AU - Martin, Nicholas G.
AU - Miaskowski, Christine
AU - Movsas, Benjamin
AU - van Noorden, Cornelis J. F.
AU - Oliveira, Joao Ricardo
AU - Ordoñana, Juan
AU - Pedersen, Nancy L.
AU - Raat, Hein
AU - Reeve, Bryce
AU - Ropka, Mary E.
AU - Shi, Quiling
AU - Shinozaki, Gen
AU - Singh, Jasvinder A.
AU - Sloan, Jeff A.
AU - Swaab, Dick
AU - Talwalker, Jayant
AU - Yang, Ping
AU - Zwinderman, Ailko H.
PY - 2013
Y1 - 2013
N2 - To describe the major findings in the literature regarding associations between biological and genetic factors and social functioning, paying special attention to: (1) heritability studies on social functioning and related concepts; (2) hypothesized biological pathways and genetic variants that could be involved in social functioning, and (3) the implications of these results for quality-of-life research. A search of Web of Science and PubMed databases was conducted using combinations of the following keywords: genetics, twins, heritability, social functioning, social adjustment, social interaction, and social dysfunction. Variability in the definitions and measures of social functioning was extensive. Moderate to high heritability was reported for social functioning and related concepts, including prosocial behavior, loneliness, and extraversion. Disorders characterized by impairments in social functioning also show substantial heritability. Genetic variants hypothesized to be involved in social functioning are related to the network of brain structures and processes that are known to affect social cognition and behavior. Better knowledge and understanding about the impact of genetic factors on social functioning is needed to help us to attain a more comprehensive view of health-related quality-of-life (HRQOL) and will ultimately enhance our ability to identify those patients who are vulnerable to poor social functioning
AB - To describe the major findings in the literature regarding associations between biological and genetic factors and social functioning, paying special attention to: (1) heritability studies on social functioning and related concepts; (2) hypothesized biological pathways and genetic variants that could be involved in social functioning, and (3) the implications of these results for quality-of-life research. A search of Web of Science and PubMed databases was conducted using combinations of the following keywords: genetics, twins, heritability, social functioning, social adjustment, social interaction, and social dysfunction. Variability in the definitions and measures of social functioning was extensive. Moderate to high heritability was reported for social functioning and related concepts, including prosocial behavior, loneliness, and extraversion. Disorders characterized by impairments in social functioning also show substantial heritability. Genetic variants hypothesized to be involved in social functioning are related to the network of brain structures and processes that are known to affect social cognition and behavior. Better knowledge and understanding about the impact of genetic factors on social functioning is needed to help us to attain a more comprehensive view of health-related quality-of-life (HRQOL) and will ultimately enhance our ability to identify those patients who are vulnerable to poor social functioning
U2 - https://doi.org/10.1007/s11136-012-0277-5
DO - https://doi.org/10.1007/s11136-012-0277-5
M3 - Review article
C2 - 23054492
SN - 0962-9343
VL - 22
SP - 1189
EP - 1200
JO - Quality of life research
JF - Quality of life research
IS - 6
ER -