TY - JOUR
T1 - Biological pathways, candidate genes, and molecular markers associated with quality-of-life domains: an update
AU - Sprangers, Mirjam A. G.
AU - Thong, Melissa S. Y.
AU - Bartels, Meike
AU - Barsevick, Andrea
AU - Ordoñana, Juan
AU - Shi, Qiuling
AU - Wang, Xin Shelley
AU - Klepstad, Pål
AU - Wierenga, Eddy A.
AU - Singh, Jasvinder A.
AU - Sloan, Jeff A.
AU - AUTHOR GROUP
AU - Abertnethy, Amy P.
AU - Baas, Frank
AU - Barsevick, Andrea M.
AU - Boomsma, Dorret I.
AU - Bottomley, Andrew
AU - Brundage, Michael
AU - Cella, David
AU - Chauhan, Cynthia
AU - Cleeland, Charles S.
AU - Coens, Corneel
AU - Dueck, Amylou C.
AU - Frost, Marlene H.
AU - Hall, Per
AU - Halyard, Michele Y.
AU - van Laarhoven, Hanneke W. M.
AU - Martin, Nicholas G.
AU - Miaskowski, Christine
AU - Mosing, Miriam
AU - Movsas, Benjamin
AU - Oliveira, Joao R.
AU - Patrick, Donald L.
AU - Pedersen, Nancy L.
AU - Raat, Hein
AU - Reeve, Bryce
AU - Stephen, Ristvedt
AU - Ropka, Mary E.
AU - Schwartz, Carolyn
AU - Shi, Quiling
AU - Shinozaki, Gen
AU - Swaab, Dick
AU - Talwalkar, Jayant
AU - Thong, Melissa
AU - van Noorden, Cornelis J. F.
AU - Veenhoven, Ruut
AU - Wagner, Gert
AU - Wierenga, Eddy
AU - Yang, Ping
AU - Zwinderman, Ailko H.
PY - 2014
Y1 - 2014
N2 - There is compelling evidence of a genetic foundation of patient-reported quality of life (QOL). Given the rapid development of substantial scientific advances in this area of research, the current paper updates and extends reviews published in 2010. The objective was to provide an updated overview of the biological pathways, candidate genes, and molecular markers involved in fatigue, pain, negative (depressed mood) and positive (well-being/happiness) emotional functioning, social functioning, and overall QOL. We followed a purposeful search algorithm of existing literature to capture empirical papers investigating the relationship between biological pathways and molecular markers and the identified QOL domains. Multiple major pathways are involved in each QOL domain. The inflammatory pathway has the strongest evidence as a controlling mechanism underlying fatigue. Inflammation and neurotransmission are key processes involved in pain perception, and the catechol-O-methyltransferase (COMT) gene is associated with multiple sorts of pain. The neurotransmitter and neuroplasticity theories have the strongest evidence for their relationship with depression. Oxytocin-related genes and genes involved in the serotonergic and dopaminergic pathways play a role in social functioning. Inflammatory pathways, via cytokines, also play an important role in overall QOL. Whereas the current findings need future experiments and replication efforts, they will provide researchers supportive background information when embarking on studies relating candidate genes and/or molecular markers to QOL domains. The ultimate goal of this area of research is to enhance patients' QOL
AB - There is compelling evidence of a genetic foundation of patient-reported quality of life (QOL). Given the rapid development of substantial scientific advances in this area of research, the current paper updates and extends reviews published in 2010. The objective was to provide an updated overview of the biological pathways, candidate genes, and molecular markers involved in fatigue, pain, negative (depressed mood) and positive (well-being/happiness) emotional functioning, social functioning, and overall QOL. We followed a purposeful search algorithm of existing literature to capture empirical papers investigating the relationship between biological pathways and molecular markers and the identified QOL domains. Multiple major pathways are involved in each QOL domain. The inflammatory pathway has the strongest evidence as a controlling mechanism underlying fatigue. Inflammation and neurotransmission are key processes involved in pain perception, and the catechol-O-methyltransferase (COMT) gene is associated with multiple sorts of pain. The neurotransmitter and neuroplasticity theories have the strongest evidence for their relationship with depression. Oxytocin-related genes and genes involved in the serotonergic and dopaminergic pathways play a role in social functioning. Inflammatory pathways, via cytokines, also play an important role in overall QOL. Whereas the current findings need future experiments and replication efforts, they will provide researchers supportive background information when embarking on studies relating candidate genes and/or molecular markers to QOL domains. The ultimate goal of this area of research is to enhance patients' QOL
U2 - https://doi.org/10.1007/s11136-014-0656-1
DO - https://doi.org/10.1007/s11136-014-0656-1
M3 - Review article
C2 - 24604075
SN - 0962-9343
VL - 23
SP - 1997
EP - 2013
JO - Quality of life research
JF - Quality of life research
IS - 7
ER -