TY - JOUR
T1 - Biomarkers indicating tissue thyroid hormone status
T2 - ready to be implemented yet?
AU - Jansen, Heleen I.
AU - Bruinstroop, Eveline
AU - Heijboer, Annemieke C.
AU - Boelen, Anita
N1 - Publisher Copyright: © 2022 Society for Endocrinology.
PY - 2022/5
Y1 - 2022/5
N2 - Currently, thyroid hormone status is predominantly determined by the measurement of serum thyroid-stimulating hormone and free thyroxine. Although it is assumed that serum thyroid hormone (TH) concentrations within the reference range represent euthyroidism, it is unknown whether this reflects euthyroidism in all tissues (e.g. brain, muscle, bone and liver). To date, no serum marker has been established for clinical use that represents TH status within tissues accurately. However, several biomarkers have been investigated and innovative techniques have been used to unravel new biomarkers. This review provides an overview of proposed serum biomarkers that reflect tissue TH status in humans. Furthermore, we discuss the feasibility of these serum markers in clinical practice.
AB - Currently, thyroid hormone status is predominantly determined by the measurement of serum thyroid-stimulating hormone and free thyroxine. Although it is assumed that serum thyroid hormone (TH) concentrations within the reference range represent euthyroidism, it is unknown whether this reflects euthyroidism in all tissues (e.g. brain, muscle, bone and liver). To date, no serum marker has been established for clinical use that represents TH status within tissues accurately. However, several biomarkers have been investigated and innovative techniques have been used to unravel new biomarkers. This review provides an overview of proposed serum biomarkers that reflect tissue TH status in humans. Furthermore, we discuss the feasibility of these serum markers in clinical practice.
KW - biomarkers
KW - metabolomics
KW - thyroid hormone
KW - tissue thyroid hormone status
UR - http://www.scopus.com/inward/record.url?scp=85128001823&partnerID=8YFLogxK
U2 - https://doi.org/10.1530/JOE-21-0364
DO - https://doi.org/10.1530/JOE-21-0364
M3 - Review article
C2 - 35256536
SN - 0022-0795
VL - 253
SP - R21-R45
JO - Journal of endocrinology
JF - Journal of endocrinology
IS - 2
ER -