TY - JOUR
T1 - Biomarkers of Coronary Artery Disease Differ Between Asians and Caucasians in the General Population
AU - Gijsberts, Crystel M.
AU - den Ruijter, Hester M.
AU - Asselbergs, Folkert W.
AU - Chan, Mark Y.
AU - de Kleijn, Dominique P. V.
AU - Hoefer, Imo E.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Coronary artery disease (CAD) markers have not been thoroughly investigated among Asians. The incidence of CAD, however, is rising rapidly in Asia. In this review, we systematically discuss publications that compare CAD biomarkers between Asians and Caucasians in the general population. A PubMed search yielded 5,570 hits, containing 59 articles describing 47 unique cohorts that directly compare Asians with Caucasians. Ten biomarkers were taken into account for this review: total cholesterol; triglycerides; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; C-reactive protein; glucose; insulin; glycated hemoglobin; fibrinogen; and plasminogen activator inhibitor-1. Triglycerides were 1.13-fold higher in South Asians than in Caucasians, and insulin levels were 1.33-fold higher. In Japanese and Chinese subjects, lower C-reactive protein levels were reported: 0.52 and 0.36-fold, respectively. Ethnicity-specific prognostic measures of CAD biomarkers were rarely reported. CAD biomarker levels differ between Asians and Caucasians and among Asian ethnic groups in population-based cohorts. The ethnicity-specific prognostic value of CAD biomarkers is yet to be determined.
AB - Coronary artery disease (CAD) markers have not been thoroughly investigated among Asians. The incidence of CAD, however, is rising rapidly in Asia. In this review, we systematically discuss publications that compare CAD biomarkers between Asians and Caucasians in the general population. A PubMed search yielded 5,570 hits, containing 59 articles describing 47 unique cohorts that directly compare Asians with Caucasians. Ten biomarkers were taken into account for this review: total cholesterol; triglycerides; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; C-reactive protein; glucose; insulin; glycated hemoglobin; fibrinogen; and plasminogen activator inhibitor-1. Triglycerides were 1.13-fold higher in South Asians than in Caucasians, and insulin levels were 1.33-fold higher. In Japanese and Chinese subjects, lower C-reactive protein levels were reported: 0.52 and 0.36-fold, respectively. Ethnicity-specific prognostic measures of CAD biomarkers were rarely reported. CAD biomarker levels differ between Asians and Caucasians and among Asian ethnic groups in population-based cohorts. The ethnicity-specific prognostic value of CAD biomarkers is yet to be determined.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84924143281&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/26014657
U2 - https://doi.org/10.1016/j.gheart.2014.11.004
DO - https://doi.org/10.1016/j.gheart.2014.11.004
M3 - Review article
C2 - 26014657
SN - 2211-8160
VL - 10
SP - 301-311.e11
JO - Global Heart
JF - Global Heart
IS - 4
ER -