Blood-brain barrier dysfunction, seizures and epilepsy

E.A. van Vliet; E. Aronica; J.A. Gorter

doi:https://doi.org/10.1016/j.semcdb.2014.10.003

Blood-brain barrier dysfunction, seizures and epilepsy

E.A. van Vliet, E. Aronica, J.A. Gorter

Research output: Contribution to journal › Article › Academic › peer-review

156 Citations (Scopus)

Abstract

The blood-brain barrier (BBB) is a dynamic and complex system which separates the brain from the blood. It helps to maintain the homeostasis of the brain, which is essential for normal neuronal functioning. BBB function is impaired in several neurological diseases, including epilepsy in which it may lead to abnormal and excessive neuronal firing. In this review we will discuss how BBB dysfunction can affect neuronal function and how this can lead to seizures and epilepsy. We will also summarize new therapies that aim to preserve or restore BBB function in order to prevent or reduce epileptogenesis.

Original language	English
Pages (from-to)	26-34
Journal	Seminars in cell & developmental biology
Volume	38
Early online date	6 Nov 2014
DOIs	https://doi.org/10.1016/j.semcdb.2014.10.003
Publication status	Published - Feb 2015

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https://doi.org/10.1016/j.semcdb.2014.10.003

https://pure.uva.nl/ws/files/2449318/159503_Blood_brain_barrier_dysfunction.pdf

Cite this

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