Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma

Esther E E Drees; Julia Driessen; Gerben J C Zwezerijnen; Sandra A W M Verkuijlen; Jakoba J Eertink; Monique A J van Eijndhoven; Nils J Groenewegen; Andrea Vallés-Martí; Daphne de Jong; Ronald Boellaard; Henrica C W de Vet; Dirk M Pegtel; Josée M Zijlstra

doi:https://doi.org/10.1002/jha2.432

Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma

Esther E E Drees, Julia Driessen, Gerben J C Zwezerijnen, Sandra A W M Verkuijlen, Jakoba J Eertink, Monique A J van Eijndhoven, Nils J Groenewegen, Andrea Vallés-Martí, Daphne de Jong, Ronald Boellaard, Henrica C W de Vet, Dirk M Pegtel, Josée M Zijlstra

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative 18F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.

Original language	English
Pages (from-to)	908-912
Number of pages	5
Journal	EJHaem
Volume	3
Issue number	3
DOIs	https://doi.org/10.1002/jha2.432
Publication status	Published - Aug 2022

Access to Document

https://doi.org/10.1002/jha2.432

Cite this

Drees, E. E. E., Driessen, J., Zwezerijnen, G. J. C., Verkuijlen, S. A. W. M., Eertink, J. J., van Eijndhoven, M. A. J., Groenewegen, N. J., Vallés-Martí, A., de Jong, D., Boellaard, R., de Vet, H. C. W., Pegtel, D. M., & Zijlstra, J. M. (2022). Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma. EJHaem, 3(3), 908-912. https://doi.org/10.1002/jha2.432

@article{625bd4b8cbeb4d0eb0722a75f51d95dc,

title = "Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma",

abstract = "Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative 18F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models. ",

author = "Drees, {Esther E E} and Julia Driessen and Zwezerijnen, {Gerben J C} and Verkuijlen, {Sandra A W M} and Eertink, {Jakoba J} and {van Eijndhoven}, {Monique A J} and Groenewegen, {Nils J} and Andrea Vall{\'e}s-Mart{\'i} and {de Jong}, Daphne and Ronald Boellaard and {de Vet}, {Henrica C W} and Pegtel, {Dirk M} and Zijlstra, {Jos{\'e}e M}",

note = "{\textcopyright} 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.",

year = "2022",

month = aug,

doi = "https://doi.org/10.1002/jha2.432",

language = "English",

volume = "3",

pages = "908--912",

journal = "EJHaem",

issn = "2688-6146",

number = "3",

}

Drees, EEE, Driessen, J, Zwezerijnen, GJC, Verkuijlen, SAWM, Eertink, JJ, van Eijndhoven, MAJ, Groenewegen, NJ, Vallés-Martí, A , de Jong, D , Boellaard, R , de Vet, HCW, Pegtel, DM & Zijlstra, JM 2022, 'Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma', EJHaem, vol. 3, no. 3, pp. 908-912. https://doi.org/10.1002/jha2.432

TY - JOUR

T1 - Blood-circulating EV-miRNAs, serum TARC, and quantitative FDG-PET features in classical Hodgkin lymphoma

AU - Drees, Esther E E

AU - Driessen, Julia

AU - Zwezerijnen, Gerben J C

AU - Verkuijlen, Sandra A W M

AU - Eertink, Jakoba J

AU - van Eijndhoven, Monique A J

AU - Groenewegen, Nils J

AU - Vallés-Martí, Andrea

AU - de Jong, Daphne

AU - Boellaard, Ronald

AU - de Vet, Henrica C W

AU - Pegtel, Dirk M

AU - Zijlstra, Josée M

PY - 2022/8

Y1 - 2022/8

N2 - Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative 18F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.

AB - Blood-based biomarkers are gaining interest for response evaluation in classical Hodgkin lymphoma (cHL). However, it is unknown how blood-based biomarkers relate to quantitative 18F-FDG-PET features. We correlated extracellular vesicle-associated miRNAs (EV-miRNA), serum TARC, and complete blood count (CBC) with PET features (e.g., metabolic tumor volume [MTV], dissemination and intensity features) in 30 cHL patients at baseline. EV-miR127-3p, EV-miR24-3p, sTARC, and several CBC parameters showed weak to strong correlations with MTV and dissemination features, but not with intensity features. Two other EV-miRNAs only showed weak correlations with PET features. Therefore, blood-based biomarkers may be complementary to PET features, which warrants further exploration of combining these biomarkers in prognostic models.

U2 - https://doi.org/10.1002/jha2.432

DO - https://doi.org/10.1002/jha2.432

M3 - Article

C2 - 36051072

SN - 2688-6146

VL - 3

SP - 908

EP - 912

JO - EJHaem

JF - EJHaem

IS - 3

ER -