TY - JOUR
T1 - Blood platelets as an RNA biomarker platform for neuro-oncological diseases
AU - Post, Edward
AU - Sol, Nik
AU - Best, Myron G.
AU - Wurdinger, Thomas
N1 - © The Author(s) 2022. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Blood-based liquid biopsies are an upcoming approach for earlier cancer detection, diagnostics, prognostics, therapy-response prediction, and therapy monitoring, including in patients with tumors of the central nervous system. Among these, liquid biopsies are plasma-derived markers such as cell-free DNA, RNA and proteins, extracellular vesicles, circulating glioma cells, immune cells, and blood platelets. Blood platelets are involved in the local and systemic response to the presence of cancer, thereby sequestering and splicing RNAs, which may be clinically useful as blood-based biomarkers. In this review, we discuss the available literature regarding the role of blood platelets in gliomas and provide suggestions for future research efforts.
AB - Blood-based liquid biopsies are an upcoming approach for earlier cancer detection, diagnostics, prognostics, therapy-response prediction, and therapy monitoring, including in patients with tumors of the central nervous system. Among these, liquid biopsies are plasma-derived markers such as cell-free DNA, RNA and proteins, extracellular vesicles, circulating glioma cells, immune cells, and blood platelets. Blood platelets are involved in the local and systemic response to the presence of cancer, thereby sequestering and splicing RNAs, which may be clinically useful as blood-based biomarkers. In this review, we discuss the available literature regarding the role of blood platelets in gliomas and provide suggestions for future research efforts.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85159216259&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36380866
U2 - https://doi.org/10.1093/noajnl/vdac043
DO - https://doi.org/10.1093/noajnl/vdac043
M3 - Article
C2 - 36380866
SN - 2632-2498
VL - 4
SP - II61-II65
JO - Neuro-oncology advances
JF - Neuro-oncology advances
IS - Suppl 2
ER -