Blood platelets as an RNA biomarker platform for neuro-oncological diseases

Edward Post; Nik Sol; Myron G Best; Thomas Wurdinger

doi:https://doi.org/10.1093/noajnl/vdac043

Blood platelets as an RNA biomarker platform for neuro-oncological diseases

Edward Post, Nik Sol, Myron G Best, Thomas Wurdinger

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Blood-based liquid biopsies are an upcoming approach for earlier cancer detection, diagnostics, prognostics, therapy-response prediction, and therapy monitoring, including in patients with tumors of the central nervous system. Among these, liquid biopsies are plasma-derived markers such as cell-free DNA, RNA and proteins, extracellular vesicles, circulating glioma cells, immune cells, and blood platelets. Blood platelets are involved in the local and systemic response to the presence of cancer, thereby sequestering and splicing RNAs, which may be clinically useful as blood-based biomarkers. In this review, we discuss the available literature regarding the role of blood platelets in gliomas and provide suggestions for future research efforts.

Original language	English
Pages (from-to)	ii61-ii65
Journal	Neuro-oncology advances
Volume	4
Issue number	Suppl 2
DOIs	https://doi.org/10.1093/noajnl/vdac043
Publication status	Published - 4 Nov 2022

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https://doi.org/10.1093/noajnl/vdac043

Cite this

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title = "Blood platelets as an RNA biomarker platform for neuro-oncological diseases",

abstract = "Blood-based liquid biopsies are an upcoming approach for earlier cancer detection, diagnostics, prognostics, therapy-response prediction, and therapy monitoring, including in patients with tumors of the central nervous system. Among these, liquid biopsies are plasma-derived markers such as cell-free DNA, RNA and proteins, extracellular vesicles, circulating glioma cells, immune cells, and blood platelets. Blood platelets are involved in the local and systemic response to the presence of cancer, thereby sequestering and splicing RNAs, which may be clinically useful as blood-based biomarkers. In this review, we discuss the available literature regarding the role of blood platelets in gliomas and provide suggestions for future research efforts.",

author = "Edward Post and Nik Sol and Best, {Myron G} and Thomas Wurdinger",

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AU - Post, Edward

AU - Sol, Nik

AU - Best, Myron G

AU - Wurdinger, Thomas

N1 - © The Author(s) 2022. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

PY - 2022/11/4

Y1 - 2022/11/4

N2 - Blood-based liquid biopsies are an upcoming approach for earlier cancer detection, diagnostics, prognostics, therapy-response prediction, and therapy monitoring, including in patients with tumors of the central nervous system. Among these, liquid biopsies are plasma-derived markers such as cell-free DNA, RNA and proteins, extracellular vesicles, circulating glioma cells, immune cells, and blood platelets. Blood platelets are involved in the local and systemic response to the presence of cancer, thereby sequestering and splicing RNAs, which may be clinically useful as blood-based biomarkers. In this review, we discuss the available literature regarding the role of blood platelets in gliomas and provide suggestions for future research efforts.

AB - Blood-based liquid biopsies are an upcoming approach for earlier cancer detection, diagnostics, prognostics, therapy-response prediction, and therapy monitoring, including in patients with tumors of the central nervous system. Among these, liquid biopsies are plasma-derived markers such as cell-free DNA, RNA and proteins, extracellular vesicles, circulating glioma cells, immune cells, and blood platelets. Blood platelets are involved in the local and systemic response to the presence of cancer, thereby sequestering and splicing RNAs, which may be clinically useful as blood-based biomarkers. In this review, we discuss the available literature regarding the role of blood platelets in gliomas and provide suggestions for future research efforts.

U2 - https://doi.org/10.1093/noajnl/vdac043

DO - https://doi.org/10.1093/noajnl/vdac043

M3 - Article

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JO - Neuro-oncology advances

JF - Neuro-oncology advances

SN - 2632-2498

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