TY - JOUR
T1 - Blood pressure-lowering interventions to prevent dementia: A systematic review andmeta-analysis
AU - van Middelaar, Tessa
AU - van Vught, Lonneke A.
AU - van Gool, Willem A.
AU - Simons, Esther M. F.
AU - van den Born, Bert-Jan H.
AU - van Charante, Eric P. Moll
AU - Richard, Edo
PY - 2018
Y1 - 2018
N2 - Our objective was to study the preventive effect of lowering blood pressure (BP) by medication and/or lifestyle changes on incident all-cause dementia, Alzheimer's disease and vascular dementia. In this systematic review, we included randomized controlled trials with a BPlowering intervention. Of the nine included trials, seven assessed the effect of antihypertensive medication and two of a lifestyle or combined intervention. In the intervention arm, 1041 out of 29 029 (3.6%) participants were diagnosed with dementia compared with 1090 out of 28 653 (3.8%) controls during a median follow-up of 3.9 years [range 2-10], resulting in a pooled risk ratio of 0.93 (95% confidence interval 0.84-1.02; I2 16%). Three trials specified dementia subtypes, with no significant effect on Alzheimer's disease or vascular dementia. To conclude, lowering BP by medication and/or lifestyle changes did not lead to a significantly reduced risk of dementia. This appeared independent of dementia subtype.
AB - Our objective was to study the preventive effect of lowering blood pressure (BP) by medication and/or lifestyle changes on incident all-cause dementia, Alzheimer's disease and vascular dementia. In this systematic review, we included randomized controlled trials with a BPlowering intervention. Of the nine included trials, seven assessed the effect of antihypertensive medication and two of a lifestyle or combined intervention. In the intervention arm, 1041 out of 29 029 (3.6%) participants were diagnosed with dementia compared with 1090 out of 28 653 (3.8%) controls during a median follow-up of 3.9 years [range 2-10], resulting in a pooled risk ratio of 0.93 (95% confidence interval 0.84-1.02; I2 16%). Three trials specified dementia subtypes, with no significant effect on Alzheimer's disease or vascular dementia. To conclude, lowering BP by medication and/or lifestyle changes did not lead to a significantly reduced risk of dementia. This appeared independent of dementia subtype.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056500079&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29927845
U2 - https://doi.org/10.1097/HJH.0000000000001829
DO - https://doi.org/10.1097/HJH.0000000000001829
M3 - Article
C2 - 29927845
SN - 0263-6352
VL - 36
SP - 1780
EP - 1787
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 9
ER -