BMP-9 expression in human traumatic heterotopic ossification: a case report

Guillaume Grenier, Elisabeth Leblanc, Nathalie Faucheux, Dominique Lauzier, Peter Kloen, Reggie C. Hamdy

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23 Citations (Scopus)


Background: Heterotopic ossification (HO) is defined as the abnormal formation of mature bone in soft tissue, notably skeletal muscle. The morbidity of HO in polytraumatized patients impacts the functional outcome, impairs rehabilitation, and increases costs due to subsequent surgical interventions. Case presentation: We present the case of a 34-year-old African male who developed severe HO around his right hip 11 days after a major trauma. Immunohistochemical analyses of resected tissue revealed that several BMPs were expressed in the HO, including highly osteogenic BMP-9. Conclusions: To the best of our knowledge, this is the first report of local BMP expression, notably BMP-9, in traumatic HO, and suggests that BMP-9, possibly through mrSCs, can contribute to HO formation in soft tissues when a suitable microenvironment is present
Original languageEnglish
Pages (from-to)29
JournalSkeletal muscle
Issue number1
Publication statusPublished - 2013

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