BMP-9 expression in human traumatic heterotopic ossification: a case report

Guillaume Grenier; Elisabeth Leblanc; Nathalie Faucheux; Dominique Lauzier; Peter Kloen; Reggie C. Hamdy

doi:https://doi.org/10.1186/2044-5040-3-29

BMP-9 expression in human traumatic heterotopic ossification: a case report

Guillaume Grenier, Elisabeth Leblanc, Nathalie Faucheux, Dominique Lauzier, Peter Kloen, Reggie C. Hamdy

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Abstract

Background: Heterotopic ossification (HO) is defined as the abnormal formation of mature bone in soft tissue, notably skeletal muscle. The morbidity of HO in polytraumatized patients impacts the functional outcome, impairs rehabilitation, and increases costs due to subsequent surgical interventions. Case presentation: We present the case of a 34-year-old African male who developed severe HO around his right hip 11 days after a major trauma. Immunohistochemical analyses of resected tissue revealed that several BMPs were expressed in the HO, including highly osteogenic BMP-9. Conclusions: To the best of our knowledge, this is the first report of local BMP expression, notably BMP-9, in traumatic HO, and suggests that BMP-9, possibly through mrSCs, can contribute to HO formation in soft tissues when a suitable microenvironment is present

Original language	English
Pages (from-to)	29
Journal	Skeletal Muscle
Volume	3
Issue number	1
DOIs	https://doi.org/10.1186/2044-5040-3-29
Publication status	Published - 2013

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https://doi.org/10.1186/2044-5040-3-29

Cite this

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title = "BMP-9 expression in human traumatic heterotopic ossification: a case report",

abstract = "Background: Heterotopic ossification (HO) is defined as the abnormal formation of mature bone in soft tissue, notably skeletal muscle. The morbidity of HO in polytraumatized patients impacts the functional outcome, impairs rehabilitation, and increases costs due to subsequent surgical interventions. Case presentation: We present the case of a 34-year-old African male who developed severe HO around his right hip 11 days after a major trauma. Immunohistochemical analyses of resected tissue revealed that several BMPs were expressed in the HO, including highly osteogenic BMP-9. Conclusions: To the best of our knowledge, this is the first report of local BMP expression, notably BMP-9, in traumatic HO, and suggests that BMP-9, possibly through mrSCs, can contribute to HO formation in soft tissues when a suitable microenvironment is present",

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T1 - BMP-9 expression in human traumatic heterotopic ossification: a case report

AU - Grenier, Guillaume

AU - Leblanc, Elisabeth

AU - Faucheux, Nathalie

AU - Lauzier, Dominique

AU - Kloen, Peter

AU - Hamdy, Reggie C.

PY - 2013

Y1 - 2013

N2 - Background: Heterotopic ossification (HO) is defined as the abnormal formation of mature bone in soft tissue, notably skeletal muscle. The morbidity of HO in polytraumatized patients impacts the functional outcome, impairs rehabilitation, and increases costs due to subsequent surgical interventions. Case presentation: We present the case of a 34-year-old African male who developed severe HO around his right hip 11 days after a major trauma. Immunohistochemical analyses of resected tissue revealed that several BMPs were expressed in the HO, including highly osteogenic BMP-9. Conclusions: To the best of our knowledge, this is the first report of local BMP expression, notably BMP-9, in traumatic HO, and suggests that BMP-9, possibly through mrSCs, can contribute to HO formation in soft tissues when a suitable microenvironment is present

AB - Background: Heterotopic ossification (HO) is defined as the abnormal formation of mature bone in soft tissue, notably skeletal muscle. The morbidity of HO in polytraumatized patients impacts the functional outcome, impairs rehabilitation, and increases costs due to subsequent surgical interventions. Case presentation: We present the case of a 34-year-old African male who developed severe HO around his right hip 11 days after a major trauma. Immunohistochemical analyses of resected tissue revealed that several BMPs were expressed in the HO, including highly osteogenic BMP-9. Conclusions: To the best of our knowledge, this is the first report of local BMP expression, notably BMP-9, in traumatic HO, and suggests that BMP-9, possibly through mrSCs, can contribute to HO formation in soft tissues when a suitable microenvironment is present

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DO - https://doi.org/10.1186/2044-5040-3-29

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