TY - JOUR
T1 - Brain structural and functional connectivity and network organization in cerebral palsy
T2 - A scoping review
AU - Jacobs, Nina P. T.
AU - Pouwels, Petra J. W.
AU - van der Krogt, Marjolein M.
AU - Meyns, Pieter
AU - Zhu, Kangdi
AU - Nelissen, Loïs
AU - Schoonmade, Linda J.
AU - Buizer, Annemieke I.
AU - van de Pol, Laura A.
N1 - Funding Information: The Research Foundation Flanders (FWO) under grant 1503915 N and the Phelps Foundation for Spasticity under grant 2016025. PM was supported by the European Commission (Horizon 2020) as a Marie Skłodowska‐Curie fellow under grant 660458; NPTJ was supported by the Gerrit Jan van Ingen Schenau Promising Young Scientist Award. Publisher Copyright: © 2023 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.
PY - 2023/9
Y1 - 2023/9
N2 - Aim: To explore altered structural and functional connectivity and network organization in cerebral palsy (CP), by clinical CP subtype (unilateral spastic, bilateral spastic, dyskinetic, and ataxic CP). Method: PubMed and Embase databases were systematically searched. Extracted data included clinical characteristics, analyses, outcome measures, and results. Results: Sixty-five studies were included, of which 50 investigated structural connectivity, and 20 investigated functional connectivity using functional magnetic resonance imaging (14 studies) or electroencephalography (six studies). Five of the 50 studies of structural connectivity and one of 14 of functional connectivity investigated whole-brain network organization. Most studies included patients with unilateral spastic CP; none included ataxic CP. Interpretation: Differences in structural and functional connectivity were observed between investigated clinical CP subtypes and typically developing individuals on a wide variety of measures, including efferent, afferent, interhemispheric, and intrahemispheric connections. Directions for future research include extending knowledge in underrepresented CP subtypes and methodologies, evaluating the prognostic potential of specific connectivity and network measures in neonates, and understanding therapeutic effects on brain connectivity.
AB - Aim: To explore altered structural and functional connectivity and network organization in cerebral palsy (CP), by clinical CP subtype (unilateral spastic, bilateral spastic, dyskinetic, and ataxic CP). Method: PubMed and Embase databases were systematically searched. Extracted data included clinical characteristics, analyses, outcome measures, and results. Results: Sixty-five studies were included, of which 50 investigated structural connectivity, and 20 investigated functional connectivity using functional magnetic resonance imaging (14 studies) or electroencephalography (six studies). Five of the 50 studies of structural connectivity and one of 14 of functional connectivity investigated whole-brain network organization. Most studies included patients with unilateral spastic CP; none included ataxic CP. Interpretation: Differences in structural and functional connectivity were observed between investigated clinical CP subtypes and typically developing individuals on a wide variety of measures, including efferent, afferent, interhemispheric, and intrahemispheric connections. Directions for future research include extending knowledge in underrepresented CP subtypes and methodologies, evaluating the prognostic potential of specific connectivity and network measures in neonates, and understanding therapeutic effects on brain connectivity.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85147510953&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36750309
UR - http://www.scopus.com/inward/record.url?scp=85147510953&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/dmcn.15516
DO - https://doi.org/10.1111/dmcn.15516
M3 - Review article
C2 - 36750309
SN - 0012-1622
VL - 65
SP - 1157
EP - 1173
JO - Developmental Medicine and Child Neurology
JF - Developmental Medicine and Child Neurology
IS - 9
ER -