TY - JOUR
T1 - Burden of disease and increasing prevalence of inflammatory bowel disease in a population-based cohort in the Netherlands
AU - de Groof, E. Joline
AU - Rossen, Noortje G. M.
AU - van Rhijn, Bram D.
AU - Karregat, Evert P. M.
AU - Boonstra, Kirsten
AU - Hageman, Ishtu
AU - Bennebroek Evertsz, Floor
AU - Kingma, Paul J.
AU - Naber, Anton H. J.
AU - van den Brande, Jan H. M.
AU - Mallant-Hent, Rosalie C.
AU - Mundt, Marco W.
AU - D'Haens, Geert R. A. M.
AU - Ponsioen, Cyriel Y.
PY - 2016
Y1 - 2016
N2 - Reported epidemiology and phenotype distributions vary widely and disease burden of inflammatory bowel disease (IBD) is poorly described. Our aim was to establish these features in a population-based cohort covering 319 976 inhabitants. Furthermore, differences between tertiary referral and peripheral hospital patients were quantified. IBD patients in the adherence area of three peripheral hospitals (2004-2012) were included. Medical and surgical treatment data were obtained. Quality of life and disease activity were evaluated. An outpatient cohort from a tertiary referral centre was accrued. A total of 1461 patients were included: 761 (52.1%) with ulcerative colitis (UC), 579 (39.5%) with Crohn's disease (CD) and 121 (8.3%) with IBD-unspecified. Point prevalence of IBD was 432.1 per 100 000 inhabitants in 2010, which increased significantly over time, P-value of less than 0.0001. The mean annual incidence was 17.2 for UC, 10.5 for CD and 2.2 for IBD-unspecified. Tertiary referral Crohn's patients used thiopurines and biological therapy and underwent surgery significantly more often than patients in peripheral hospitals (P <0.0001). Disease activity correlated negatively with quality of life (P <0.0001) in UC and CD. The prevalence of IBD is still increasing. Burden of disease was significantly more severe, mainly in Crohn's patients, in the referral centre, highlighting the importance of population-based studies to accurately describe phenotype distribution and disease burden
AB - Reported epidemiology and phenotype distributions vary widely and disease burden of inflammatory bowel disease (IBD) is poorly described. Our aim was to establish these features in a population-based cohort covering 319 976 inhabitants. Furthermore, differences between tertiary referral and peripheral hospital patients were quantified. IBD patients in the adherence area of three peripheral hospitals (2004-2012) were included. Medical and surgical treatment data were obtained. Quality of life and disease activity were evaluated. An outpatient cohort from a tertiary referral centre was accrued. A total of 1461 patients were included: 761 (52.1%) with ulcerative colitis (UC), 579 (39.5%) with Crohn's disease (CD) and 121 (8.3%) with IBD-unspecified. Point prevalence of IBD was 432.1 per 100 000 inhabitants in 2010, which increased significantly over time, P-value of less than 0.0001. The mean annual incidence was 17.2 for UC, 10.5 for CD and 2.2 for IBD-unspecified. Tertiary referral Crohn's patients used thiopurines and biological therapy and underwent surgery significantly more often than patients in peripheral hospitals (P <0.0001). Disease activity correlated negatively with quality of life (P <0.0001) in UC and CD. The prevalence of IBD is still increasing. Burden of disease was significantly more severe, mainly in Crohn's patients, in the referral centre, highlighting the importance of population-based studies to accurately describe phenotype distribution and disease burden
U2 - https://doi.org/10.1097/MEG.0000000000000660
DO - https://doi.org/10.1097/MEG.0000000000000660
M3 - Article
C2 - 27281507
SN - 0954-691X
VL - 28
SP - 1065
EP - 1072
JO - European Journal of Gastroenterology & Hepatology
JF - European Journal of Gastroenterology & Hepatology
IS - 9
ER -