C-reactive protein is a mediator of cardiovascular disease

Radjesh J. Bisoendial, S. Matthijs Boekholdt, Menno Vergeer, Erik S. G. Stroes, John J. P. Kastelein

Research output: Contribution to journalReview articleAcademicpeer-review

151 Citations (Scopus)


C-reactive protein is postulated to embody an index that can reflect cardiovascular risk and can be used to independently predict major cardiovascular events and mortality. On the other hand, credible experimental data have become available that demonstrate the abundant presence of C-reactive protein in atherosclerotic lesions and, moreover, identify C-reactive protein as an initiator of several pathogenic pathways that can cause atherogenic changes. Consequently, there has been a paradigm shift in which C-reactive protein is no longer regarded as merely an indicator of cardiovascular risk, but increasingly considered a direct partaker in the pathogenesis of atherosclerotic cardiovascular disease. These data underscore the need to explore risk-reducing interventions that selectively inhibit C-reactive protein activity as a novel strategy to prevent clinical manifestations of atherosclerosis
Original languageEnglish
Pages (from-to)2087-U1505
JournalEuropean Heart journal
Issue number17
Publication statusPublished - 2010

Cite this