TY - JOUR
T1 - C11-oxy C19 and C11-oxy C21 steroids in neonates: UPC2-MS/MS quantification of plasma 11β-hydroxyandrostenedione, 11-ketotestosterone and 11-ketoprogesterone
AU - du Toit, Therina
AU - Finken, Martijn J. J.
AU - Hamer, Henrike M.
AU - Heijboer, Annemieke C.
AU - Swart, Amanda C.
PY - 2018
Y1 - 2018
N2 - The purpose of this study was to identify the C11-oxy C19 and C11-oxy C21 steroids in male and female neonate plasma. At birth, the most abundant C11-oxy steroids detected in neonatal plasma were 11β-hydroxyandrostenedione, ∼13 nM, and 11-ketoprogesterone, ∼23 nM. C11-oxy C19 steroids were higher than C19 steroids in neonatal plasma, 22.2 nM vs 5.4 nM. The inclusion of C11-oxy C19 and C21 steroid reference ranges in routine steroid analyses will assist the characterization of disorders associated with impaired steroidogenic enzyme expression and the identification of potential biomarkers.
AB - The purpose of this study was to identify the C11-oxy C19 and C11-oxy C21 steroids in male and female neonate plasma. At birth, the most abundant C11-oxy steroids detected in neonatal plasma were 11β-hydroxyandrostenedione, ∼13 nM, and 11-ketoprogesterone, ∼23 nM. C11-oxy C19 steroids were higher than C19 steroids in neonatal plasma, 22.2 nM vs 5.4 nM. The inclusion of C11-oxy C19 and C21 steroid reference ranges in routine steroid analyses will assist the characterization of disorders associated with impaired steroidogenic enzyme expression and the identification of potential biomarkers.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048276703&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29883615
U2 - https://doi.org/10.1016/j.steroids.2018.06.003
DO - https://doi.org/10.1016/j.steroids.2018.06.003
M3 - Article
C2 - 29883615
SN - 0039-128X
VL - 138
SP - 1
EP - 5
JO - Steroids
JF - Steroids
ER -