TY - JOUR
T1 - Transmission of Antibiotic-Susceptible Escherichia coli Causing Urinary Tract Infections in a Fecal Microbiota Transplantation Recipient
T2 - Consequences for Donor Screening?
AU - Vendrik, Karuna E. W.
AU - de Meij, Tim G. J.
AU - Bökenkamp, Arend
AU - Ooijevaar, Rogier E.
AU - Groenewegen, Bas
AU - Hendrickx, Antoni P. A.
AU - Terveer, Elisabeth M.
AU - Kuijper, Ed J.
AU - van Prehn, Joffrey
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Fecal microbiota transplantation (FMT) has been reported to decrease the incidence of recurrent urinary tract infections (UTIs), presumably by restoring microbiome diversity and/or uropathogen competition. We report a 16-year-old female with recurrent UTIs caused by multidrug-resistant Klebsiella pneumoniae, for which frequent intravenous broad-spectrum antibiotic treatment was necessary. The patient was treated with FMT from a well-screened healthy donor without multidrug-resistant bacteria in the feces. After FMT, she developed several UTIs with an antibiotic-susceptible Escherichia coli that could be treated orally. The uropathogenic E. coli could be cultured from donor feces, and whole genome sequencing confirmed donor-to-recipient transmission. Our observation should stimulate discussion on long-term follow-up of all infections after FMT and donor fecal screening for antibiotic-susceptible Enterobacterales.
AB - Fecal microbiota transplantation (FMT) has been reported to decrease the incidence of recurrent urinary tract infections (UTIs), presumably by restoring microbiome diversity and/or uropathogen competition. We report a 16-year-old female with recurrent UTIs caused by multidrug-resistant Klebsiella pneumoniae, for which frequent intravenous broad-spectrum antibiotic treatment was necessary. The patient was treated with FMT from a well-screened healthy donor without multidrug-resistant bacteria in the feces. After FMT, she developed several UTIs with an antibiotic-susceptible Escherichia coli that could be treated orally. The uropathogenic E. coli could be cultured from donor feces, and whole genome sequencing confirmed donor-to-recipient transmission. Our observation should stimulate discussion on long-term follow-up of all infections after FMT and donor fecal screening for antibiotic-susceptible Enterobacterales.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85159312366&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/35899275
U2 - https://doi.org/10.1093/ofid/ofac324
DO - https://doi.org/10.1093/ofid/ofac324
M3 - Article
C2 - 35899275
SN - 2328-8957
VL - 9
JO - Open forum infectious diseases
JF - Open forum infectious diseases
IS - 7
M1 - ofac324
ER -