A road map for the treatment of pediatric diffuse midline glioma

Carl Koschmann; Wajd N. Al-Holou; Marta M. Alonso; Jamie Anastas; Pratiti Bandopadhayay; Tara Barron; Oren Becher; Rodrigo Cartaxo; Maria G. Castro; Chan Chung; Madison Clausen; Derek Dang; Robert Doherty; Ryan Duchatel; Matthew Dun; Mariella Filbin; Andrea Franson; Stefanie Galban; Marc Garcia Moure; Hugh Garton; Pruthvi Gowda; Joana Graca Marques; Cynthia Hawkins; Allison Heath; Esther Hulleman; Sunjong Ji; Chris Jones; Lindsay Kilburn; Cassie Kline; Michael A. Koldobskiy; Daniel Lim; Pedro R. Lowenstein; Q. Richard Lu; Joanna Lum; Stephen Mack; Suresh Magge; Bernard Marini; Donna Martin; Neena Marupudi; Dana Messinger; Rajen Mody; Meredith Morgan; Mateus Mota; Karin Muraszko; Sabine Mueller; Siva Kumar Natarajan; Javad Nazarian; Michael Niculcea; Nicholas Nuechterlein; Hideho Okada; Valerie Opipari; Manjunath P. Pai; Sharmistha Pal; Erik Peterson; Timothy Phoenix; John R. Prensner; Matthew Pun; G. Praveen Raju; Zachary J. Reitman; Adam Resnick; David Rogawski; Amanda Saratsis; Stefanie G. Sbergio; Mark Souweidane; James M. Stafford; Theophilos Tzaridis; Sujatha Venkataraman; Orazio Vittorio; Jack Wadden; Daniel Wahl; Robert J. Wechsler-Reya; Viveka Nand Yadav; Xu Zhang; Qiang Zhang; Sriram Venneti

doi:https://doi.org/10.1016/j.ccell.2023.11.002

A road map for the treatment of pediatric diffuse midline glioma

Carl Koschmann, Wajd N. Al-Holou, Marta M. Alonso, Jamie Anastas, Pratiti Bandopadhayay, Tara Barron, Oren Becher, Rodrigo Cartaxo, Maria G. Castro, Chan Chung, Madison Clausen, Derek Dang, Robert Doherty, Ryan Duchatel, Matthew Dun, Mariella Filbin, Andrea Franson, Stefanie Galban, Marc Garcia Moure, Hugh GartonPruthvi Gowda, Joana Graca Marques, Cynthia Hawkins, Allison Heath, Esther Hulleman, Sunjong Ji, Chris Jones, Lindsay Kilburn, Cassie Kline, Michael A. Koldobskiy, Daniel Lim, Pedro R. Lowenstein, Q. Richard Lu, Joanna Lum, Stephen Mack, Suresh Magge, Bernard Marini, Donna Martin, Neena Marupudi, Dana Messinger, Rajen Mody, Meredith Morgan, Mateus Mota, Karin Muraszko, Sabine Mueller, Siva Kumar Natarajan, Javad Nazarian, Michael Niculcea, Nicholas Nuechterlein, Hideho Okada, Valerie Opipari, Manjunath P. Pai, Sharmistha Pal, Erik Peterson, Timothy Phoenix, John R. Prensner, Matthew Pun, G. Praveen Raju, Zachary J. Reitman, Adam Resnick, David Rogawski, Amanda Saratsis, Stefanie G. Sbergio, Mark Souweidane, James M. Stafford, Theophilos Tzaridis, Sujatha Venkataraman, Orazio Vittorio, Jack Wadden, Daniel Wahl, Robert J. Wechsler-Reya, Viveka Nand Yadav, Xu Zhang, Qiang Zhang, Sriram Venneti

Paediatric (VUmc)

Research output: Contribution to journal › Comment/Letter to the editor › Academic

1 Citation (Scopus)

Abstract

Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Cancer cell
Volume	42
Issue number	1
DOIs	https://doi.org/10.1016/j.ccell.2023.11.002
Publication status	Published - 8 Jan 2024

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Koschmann, C., Al-Holou, W. N., Alonso, M. M., Anastas, J., Bandopadhayay, P., Barron, T., Becher, O., Cartaxo, R., Castro, M. G., Chung, C., Clausen, M., Dang, D., Doherty, R., Duchatel, R., Dun, M., Filbin, M., Franson, A., Galban, S., Garcia Moure, M., ... Venneti, S. (2024). A road map for the treatment of pediatric diffuse midline glioma. Cancer cell, 42(1), 1-5. https://doi.org/10.1016/j.ccell.2023.11.002

@article{c65449838380457799b7045900b71be5,

title = "A road map for the treatment of pediatric diffuse midline glioma",

abstract = "Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.",

author = "Carl Koschmann and Al-Holou, {Wajd N.} and Alonso, {Marta M.} and Jamie Anastas and Pratiti Bandopadhayay and Tara Barron and Oren Becher and Rodrigo Cartaxo and Castro, {Maria G.} and Chan Chung and Madison Clausen and Derek Dang and Robert Doherty and Ryan Duchatel and Matthew Dun and Mariella Filbin and Andrea Franson and Stefanie Galban and {Garcia Moure}, Marc and Hugh Garton and Pruthvi Gowda and Marques, {Joana Graca} and Cynthia Hawkins and Allison Heath and Esther Hulleman and Sunjong Ji and Chris Jones and Lindsay Kilburn and Cassie Kline and Koldobskiy, {Michael A.} and Daniel Lim and Lowenstein, {Pedro R.} and Lu, {Q. Richard} and Joanna Lum and Stephen Mack and Suresh Magge and Bernard Marini and Donna Martin and Neena Marupudi and Dana Messinger and Rajen Mody and Meredith Morgan and Mateus Mota and Karin Muraszko and Sabine Mueller and Natarajan, {Siva Kumar} and Javad Nazarian and Michael Niculcea and Nicholas Nuechterlein and Hideho Okada and Valerie Opipari and Pai, {Manjunath P.} and Sharmistha Pal and Erik Peterson and Timothy Phoenix and Prensner, {John R.} and Matthew Pun and Raju, {G. Praveen} and Reitman, {Zachary J.} and Adam Resnick and David Rogawski and Amanda Saratsis and Sbergio, {Stefanie G.} and Mark Souweidane and Stafford, {James M.} and Theophilos Tzaridis and Sujatha Venkataraman and Orazio Vittorio and Jack Wadden and Daniel Wahl and Wechsler-Reya, {Robert J.} and Yadav, {Viveka Nand} and Xu Zhang and Qiang Zhang and Sriram Venneti",

note = "Funding Information: The authors acknowledge funding from the National Institutes of Health (grant nos. R01-NS119231 and R01-NS124607 to C.K. and R01-NS110572 , R01-CA261926 , and R01-NS127799 to S.V.) and a DOD grant ( CA201129P1 ) to C.K. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2024",

month = jan,

day = "8",

doi = "https://doi.org/10.1016/j.ccell.2023.11.002",

language = "English",

volume = "42",

pages = "1--5",

journal = "Cancer cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "1",

}

Koschmann, C, Al-Holou, WN, Alonso, MM, Anastas, J, Bandopadhayay, P, Barron, T, Becher, O, Cartaxo, R, Castro, MG, Chung, C, Clausen, M, Dang, D, Doherty, R, Duchatel, R, Dun, M, Filbin, M, Franson, A, Galban, S, Garcia Moure, M, Garton, H, Gowda, P, Marques, JG, Hawkins, C, Heath, A, Hulleman, E, Ji, S, Jones, C, Kilburn, L, Kline, C, Koldobskiy, MA, Lim, D, Lowenstein, PR, Lu, QR, Lum, J, Mack, S, Magge, S, Marini, B, Martin, D, Marupudi, N, Messinger, D, Mody, R, Morgan, M, Mota, M, Muraszko, K, Mueller, S, Natarajan, SK, Nazarian, J, Niculcea, M, Nuechterlein, N, Okada, H, Opipari, V, Pai, MP, Pal, S, Peterson, E, Phoenix, T, Prensner, JR, Pun, M, Raju, GP, Reitman, ZJ, Resnick, A, Rogawski, D, Saratsis, A, Sbergio, SG, Souweidane, M, Stafford, JM, Tzaridis, T, Venkataraman, S, Vittorio, O, Wadden, J, Wahl, D, Wechsler-Reya, RJ, Yadav, VN, Zhang, X, Zhang, Q & Venneti, S 2024, 'A road map for the treatment of pediatric diffuse midline glioma', Cancer cell, vol. 42, no. 1, pp. 1-5. https://doi.org/10.1016/j.ccell.2023.11.002

TY - JOUR

T1 - A road map for the treatment of pediatric diffuse midline glioma

AU - Koschmann, Carl

AU - Al-Holou, Wajd N.

AU - Alonso, Marta M.

AU - Anastas, Jamie

AU - Bandopadhayay, Pratiti

AU - Barron, Tara

AU - Becher, Oren

AU - Cartaxo, Rodrigo

AU - Castro, Maria G.

AU - Chung, Chan

AU - Clausen, Madison

AU - Dang, Derek

AU - Doherty, Robert

AU - Duchatel, Ryan

AU - Dun, Matthew

AU - Filbin, Mariella

AU - Franson, Andrea

AU - Galban, Stefanie

AU - Garcia Moure, Marc

AU - Garton, Hugh

AU - Gowda, Pruthvi

AU - Marques, Joana Graca

AU - Hawkins, Cynthia

AU - Heath, Allison

AU - Hulleman, Esther

AU - Ji, Sunjong

AU - Jones, Chris

AU - Kilburn, Lindsay

AU - Kline, Cassie

AU - Koldobskiy, Michael A.

AU - Lim, Daniel

AU - Lowenstein, Pedro R.

AU - Lu, Q. Richard

AU - Lum, Joanna

AU - Mack, Stephen

AU - Magge, Suresh

AU - Marini, Bernard

AU - Martin, Donna

AU - Marupudi, Neena

AU - Messinger, Dana

AU - Mody, Rajen

AU - Morgan, Meredith

AU - Mota, Mateus

AU - Muraszko, Karin

AU - Mueller, Sabine

AU - Natarajan, Siva Kumar

AU - Nazarian, Javad

AU - Niculcea, Michael

AU - Nuechterlein, Nicholas

AU - Okada, Hideho

AU - Opipari, Valerie

AU - Pai, Manjunath P.

AU - Pal, Sharmistha

AU - Peterson, Erik

AU - Phoenix, Timothy

AU - Prensner, John R.

AU - Pun, Matthew

AU - Raju, G. Praveen

AU - Reitman, Zachary J.

AU - Resnick, Adam

AU - Rogawski, David

AU - Saratsis, Amanda

AU - Sbergio, Stefanie G.

AU - Souweidane, Mark

AU - Stafford, James M.

AU - Tzaridis, Theophilos

AU - Venkataraman, Sujatha

AU - Vittorio, Orazio

AU - Wadden, Jack

AU - Wahl, Daniel

AU - Wechsler-Reya, Robert J.

AU - Yadav, Viveka Nand

AU - Zhang, Xu

AU - Zhang, Qiang

AU - Venneti, Sriram

N1 - Funding Information: The authors acknowledge funding from the National Institutes of Health (grant nos. R01-NS119231 and R01-NS124607 to C.K. and R01-NS110572 , R01-CA261926 , and R01-NS127799 to S.V.) and a DOD grant ( CA201129P1 ) to C.K. Publisher Copyright: © 2023 Elsevier Inc.

PY - 2024/1/8

Y1 - 2024/1/8

N2 - Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.

AB - Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.

UR - http://www.scopus.com/inward/record.url?scp=85181816941&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.ccell.2023.11.002

DO - https://doi.org/10.1016/j.ccell.2023.11.002

M3 - Comment/Letter to the editor

C2 - 38039965

SN - 1535-6108

VL - 42

SP - 1

EP - 5

JO - Cancer cell

JF - Cancer cell

IS - 1

ER -

A road map for the treatment of pediatric diffuse midline glioma

Abstract

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