Can we incorporate MRD assessment into clinical practice in AML?

Research output: Contribution to journalReview articleAcademicpeer-review

18 Citations (Scopus)


Measurable residual disease (MRD) can be assessed either by flow cytometry or molecular techniques. It has been proven to be highly prognostic in quite a number of prospective clinical studies. The recently published ELN MRD recommendations aim harmonize the approaches to MRD assessment in order to improve its overall quality. The predictive value leading to the usage as a surrogate endpoint for survival which would be instrumental for faster drug approvals has still to be proven. Nevertheless, many AML centers use MRD status to inform treatment.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalBest Practice and Research: Clinical Haematology
Issue number2
Publication statusPublished - 1 Jun 2019


  • AML
  • Allogeneic stem cell transplantation
  • Leukemic stem cells
  • Measurable residual disease (MRD)
  • Multicolor flowcytometry
  • qPCR

Cite this