Can we spice up our Christmas dinner? : Busting the myth of the 'Chinese restaurant syndrome'

N W E van den Berg; J Neefs; W R Berger; S W E Baalman; E Meulendijks; M Kawasaki; E M Kemper; F R Piersma; M W Veldkamp; R Wesselink; S P J Krul; J R de Groot

doi:https://doi.org/10.1007/s12471-017-1053-5

Can we spice up our Christmas dinner? : Busting the myth of the 'Chinese restaurant syndrome'

N W E van den Berg, J Neefs, W R Berger, S W E Baalman, E Meulendijks, M Kawasaki, E M Kemper, F R Piersma, M W Veldkamp, R Wesselink, S P J Krul, J R de Groot

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

BACKGROUND: Monosodium glutamate (MSG), also referred to as Vetsin or E621, is a flavour enhancer frequently used in Asian cuisine and abundantly present in the famous Chinese dish Peking duck. MSG is notorious for triggering the onset of the so-called 'Chinese restaurant syndrome' (CRS), a complex of unpleasant symptoms, which might include flushing, sweating and the onset of atrial fibrillation (AF). This study aims to determine the effects of MSG on the occurrence of AF.

METHODS: We conducted a placebo self-controlled single-arm study in the Academic Medical Centre in Amsterdam. We included paroxysmal AF patients who reported a consistent onset of AF upon MSG intake. During three admissions, participants were subsequently administered: placebo, 1.5 g and 3 g MSG. If AF was recorded after the dose of 1.5 g MSG, patients were given another placebo instead of 3 g MSG. The primary outcome was the onset of AF registered by 24-hour Holter monitoring. The secondary outcomes were any other arrhythmia and the onset of CRS defined as two or more symptoms of CRS after MSG intake.

RESULTS: Six men participated in the study. Both 1.5 g and 3 g MSG were unrelated to CRS, arrhythmias or AF occurrence.

CONCLUSION: Peking duck can be put on the Christmas menu without risking guests to be admitted to the emergency department with new episodes of AF.

Original language	English
Pages (from-to)	664-668
Number of pages	5
Journal	Netherlands heart journal
Volume	25
Issue number	12
DOIs	https://doi.org/10.1007/s12471-017-1053-5
Publication status	Published - 2017

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https://doi.org/10.1007/s12471-017-1053-5

Cite this

van den Berg, N. W. E., Neefs, J., Berger, W. R., Baalman, S. W. E., Meulendijks, E., Kawasaki, M., Kemper, E. M., Piersma, F. R., Veldkamp, M. W., Wesselink, R., Krul, S. P. J., & de Groot, J. R. (2017). Can we spice up our Christmas dinner? : Busting the myth of the 'Chinese restaurant syndrome'. Netherlands heart journal, 25(12), 664-668. https://doi.org/10.1007/s12471-017-1053-5

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title = "Can we spice up our Christmas dinner? : Busting the myth of the 'Chinese restaurant syndrome'",

abstract = "BACKGROUND: Monosodium glutamate (MSG), also referred to as Vetsin or E621, is a flavour enhancer frequently used in Asian cuisine and abundantly present in the famous Chinese dish Peking duck. MSG is notorious for triggering the onset of the so-called 'Chinese restaurant syndrome' (CRS), a complex of unpleasant symptoms, which might include flushing, sweating and the onset of atrial fibrillation (AF). This study aims to determine the effects of MSG on the occurrence of AF.METHODS: We conducted a placebo self-controlled single-arm study in the Academic Medical Centre in Amsterdam. We included paroxysmal AF patients who reported a consistent onset of AF upon MSG intake. During three admissions, participants were subsequently administered: placebo, 1.5 g and 3 g MSG. If AF was recorded after the dose of 1.5 g MSG, patients were given another placebo instead of 3 g MSG. The primary outcome was the onset of AF registered by 24-hour Holter monitoring. The secondary outcomes were any other arrhythmia and the onset of CRS defined as two or more symptoms of CRS after MSG intake.RESULTS: Six men participated in the study. Both 1.5 g and 3 g MSG were unrelated to CRS, arrhythmias or AF occurrence.CONCLUSION: Peking duck can be put on the Christmas menu without risking guests to be admitted to the emergency department with new episodes of AF.",

author = "{van den Berg}, {N W E} and J Neefs and Berger, {W R} and Baalman, {S W E} and E Meulendijks and M Kawasaki and Kemper, {E M} and Piersma, {F R} and Veldkamp, {M W} and R Wesselink and Krul, {S P J} and {de Groot}, {J R}",

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T1 - Can we spice up our Christmas dinner? : Busting the myth of the 'Chinese restaurant syndrome'

AU - van den Berg, N W E

AU - Neefs, J

AU - Berger, W R

AU - Baalman, S W E

AU - Meulendijks, E

AU - Kawasaki, M

AU - Kemper, E M

AU - Piersma, F R

AU - Veldkamp, M W

AU - Wesselink, R

AU - Krul, S P J

AU - de Groot, J R

PY - 2017

Y1 - 2017

N2 - BACKGROUND: Monosodium glutamate (MSG), also referred to as Vetsin or E621, is a flavour enhancer frequently used in Asian cuisine and abundantly present in the famous Chinese dish Peking duck. MSG is notorious for triggering the onset of the so-called 'Chinese restaurant syndrome' (CRS), a complex of unpleasant symptoms, which might include flushing, sweating and the onset of atrial fibrillation (AF). This study aims to determine the effects of MSG on the occurrence of AF.METHODS: We conducted a placebo self-controlled single-arm study in the Academic Medical Centre in Amsterdam. We included paroxysmal AF patients who reported a consistent onset of AF upon MSG intake. During three admissions, participants were subsequently administered: placebo, 1.5 g and 3 g MSG. If AF was recorded after the dose of 1.5 g MSG, patients were given another placebo instead of 3 g MSG. The primary outcome was the onset of AF registered by 24-hour Holter monitoring. The secondary outcomes were any other arrhythmia and the onset of CRS defined as two or more symptoms of CRS after MSG intake.RESULTS: Six men participated in the study. Both 1.5 g and 3 g MSG were unrelated to CRS, arrhythmias or AF occurrence.CONCLUSION: Peking duck can be put on the Christmas menu without risking guests to be admitted to the emergency department with new episodes of AF.

AB - BACKGROUND: Monosodium glutamate (MSG), also referred to as Vetsin or E621, is a flavour enhancer frequently used in Asian cuisine and abundantly present in the famous Chinese dish Peking duck. MSG is notorious for triggering the onset of the so-called 'Chinese restaurant syndrome' (CRS), a complex of unpleasant symptoms, which might include flushing, sweating and the onset of atrial fibrillation (AF). This study aims to determine the effects of MSG on the occurrence of AF.METHODS: We conducted a placebo self-controlled single-arm study in the Academic Medical Centre in Amsterdam. We included paroxysmal AF patients who reported a consistent onset of AF upon MSG intake. During three admissions, participants were subsequently administered: placebo, 1.5 g and 3 g MSG. If AF was recorded after the dose of 1.5 g MSG, patients were given another placebo instead of 3 g MSG. The primary outcome was the onset of AF registered by 24-hour Holter monitoring. The secondary outcomes were any other arrhythmia and the onset of CRS defined as two or more symptoms of CRS after MSG intake.RESULTS: Six men participated in the study. Both 1.5 g and 3 g MSG were unrelated to CRS, arrhythmias or AF occurrence.CONCLUSION: Peking duck can be put on the Christmas menu without risking guests to be admitted to the emergency department with new episodes of AF.

U2 - https://doi.org/10.1007/s12471-017-1053-5

DO - https://doi.org/10.1007/s12471-017-1053-5

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