TY - JOUR
T1 - Canine X-linked muscular dystrophy in a family of Grand Basset Griffon Vendéen dogs
AU - Klarenbeek, S.
AU - Gerritzen-Bruning, M. J.
AU - Rozemuller, A. J. M.
AU - van der Lugt, J. J.
PY - 2007/11/1
Y1 - 2007/11/1
N2 - Three related Grand Basset Griffon Vendéen (GBGV) dogs, two male and one female, with poor locomotion and muscle pain on palpation, were humanely destroyed at approximately 2 months of age and submitted for necropsy. Histopathological examination of skeletal muscles showed hyaline hypereosinophilic myofibres, hypertrophy and atrophy, calcification, necrosis, and mild proliferation of endomyseal connective tissue, as well as small basophilic fibres with internalized nuclei in rows, indicating regeneration. Immunohistochemical labelling for the carboxy-terminal domain of dystrophin, performed on skeletal muscle from one of the male dogs, was negative, whereas it was positive in skeletal muscle from a normal control dog. Both parents were clinically unaffected. These findings confirmed the diagnosis of canine X-linked muscular dystrophy (CXMD). To the authors' knowledge, this is the first report of CXMD in the GBGV breed, and one of very few cases in a female dog
AB - Three related Grand Basset Griffon Vendéen (GBGV) dogs, two male and one female, with poor locomotion and muscle pain on palpation, were humanely destroyed at approximately 2 months of age and submitted for necropsy. Histopathological examination of skeletal muscles showed hyaline hypereosinophilic myofibres, hypertrophy and atrophy, calcification, necrosis, and mild proliferation of endomyseal connective tissue, as well as small basophilic fibres with internalized nuclei in rows, indicating regeneration. Immunohistochemical labelling for the carboxy-terminal domain of dystrophin, performed on skeletal muscle from one of the male dogs, was negative, whereas it was positive in skeletal muscle from a normal control dog. Both parents were clinically unaffected. These findings confirmed the diagnosis of canine X-linked muscular dystrophy (CXMD). To the authors' knowledge, this is the first report of CXMD in the GBGV breed, and one of very few cases in a female dog
KW - dog
KW - muscular dystrophy
UR - http://www.scopus.com/inward/record.url?scp=35748945143&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jcpa.2007.06.007
DO - https://doi.org/10.1016/j.jcpa.2007.06.007
M3 - Article
C2 - 17888939
SN - 0021-9975
VL - 137
SP - 249
EP - 252
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
IS - 4
ER -