Carbamazepine en quetiapine: een onderbelichte, maar zeer relevante interactie

Translated title of the contribution: Carbamazepine and quetiapine: A neglected, but highly relevant interaction

Suzanne van der Gaag, Ralph W. Kupka, Pierre M. Bet

Research output: Contribution to journalArticleProfessional


We describe a case of concomitant use of carbamazepine and quetiapine, with a highly relevant interaction that requires attention. The combination of these drugs can be prescribed in psychiatry, for example in bipolar disorder, but also in other disciplines. Pharmacotherapy is one of the cornerstones in the treatment of bipolar disorders, and a combination of drugs is frequently used. Carbamazepine, an anti-epileptic drug that is effective as a mood stabilizer, and quetiapine, a second-generation antipsychotic, are both recommended in the Dutch guideline. Besides monotherapy is a combination of both drugs possible. It is striking that carbamazepine and quetiapine have a strong pharmacokinetic interaction via the metabolizing liver enzyme, CYP3A4. This interaction results in a factor 10 reduction of quetiapine blood levels. This may result in a possible loss of clinical efficacy of quetiapine.
Translated title of the contributionCarbamazepine and quetiapine: A neglected, but highly relevant interaction
Original languageDutch
Pages (from-to)794-797
Number of pages4
JournalTijdschrift voor Psychiatrie
Issue number9
Publication statusPublished - 1 Jan 2020


  • Bipolar disorder
  • Carbamazepine
  • Combination therapy
  • Interaction
  • Pharmacokinetics

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