TY - JOUR
T1 - Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease
AU - Devalla, H.D.
PY - 2018/4
Y1 - 2018/4
N2 - Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.
AB - Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045110754&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29618562
U2 - https://doi.org/10.1126/scitranslmed.aah5457
DO - https://doi.org/10.1126/scitranslmed.aah5457
M3 - Review article
C2 - 29618562
SN - 1946-6234
VL - 10
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 435
M1 - eaah5457
ER -