Cardiovascular disease in systemic lupus erythematosus: has the time for action come?

Sander I. van Leuven, John J. P. Kastelein, Michael R. Hayden, David d'Cruz, Graham R. Hughes, Erik S. Stroes

Research output: Contribution to journalReview articleAcademicpeer-review

7 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: The recognition that inflammation is a hallmark of atherosclerotic disease has led to a series of studies reporting accelerated atherogenesis in chronic inflammatory diseases. Indeed, systemic lupus erythematosus is associated with an increased incidence of cardiovascular disease and the etiology thereof deserves closer attention. RECENT FINDINGS: The association between systemic lupus erythematosus and accelerated atherosclerosis has recently been confirmed by surrogate-marker studies for cardiovascular disease in patients with systemic lupus erythematosus. Since the propensity towards cardiovascular disease cannot solely be explained by classical risk factors, disease-specific pathways have been put forward as additional risk factors. SUMMARY: In the present review, we will discuss several of these factors as well as their potential impact for future prevention strategies in systemic lupus erythematosus
Original languageEnglish
Pages (from-to)501-506
JournalCurrent opinion in lipidology
Volume16
Issue number5
DOIs
Publication statusPublished - 2005

Cite this