Cardiovascular instability and baroreflex activity in a patient with tetanus

J. J. van Lieshout; W. Wieling; J. J. Settels; J. M. Karemaker

Cardiovascular instability and baroreflex activity in a patient with tetanus

J. J. van Lieshout, W. Wieling, J. J. Settels, J. M. Karemaker

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

In a patient with tetanus we tested the hypothesis that the hyperadrenergic cardiovascular instability might be due to impairment of the baroreceptor reflex by the tetanus toxin. Baroreflex sensitivity assessed with the phenylephrine method was found to be normal. Changes in arterial pressure correlated inversely with relative changes in plasma volume but not with plasma catecholamine levels. There were both extreme hypo- and hyper-adrenergic episodes. We conclude that sympathetic overactivity in tetanus temporarily overrules a functionally intact baroreflex leading to severe blood pressure instability with episodes of hypertension

Original language	English
Pages (from-to)	5-8
Journal	CLINICAL AUTONOMIC RESEARCH
Volume	1
Issue number	1
Publication status	Published - 1991

Cite this

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title = "Cardiovascular instability and baroreflex activity in a patient with tetanus",

abstract = "In a patient with tetanus we tested the hypothesis that the hyperadrenergic cardiovascular instability might be due to impairment of the baroreceptor reflex by the tetanus toxin. Baroreflex sensitivity assessed with the phenylephrine method was found to be normal. Changes in arterial pressure correlated inversely with relative changes in plasma volume but not with plasma catecholamine levels. There were both extreme hypo- and hyper-adrenergic episodes. We conclude that sympathetic overactivity in tetanus temporarily overrules a functionally intact baroreflex leading to severe blood pressure instability with episodes of hypertension",

author = "{van Lieshout}, {J. J.} and W. Wieling and Settels, {J. J.} and Karemaker, {J. M.}",

year = "1991",

language = "English",

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T1 - Cardiovascular instability and baroreflex activity in a patient with tetanus

AU - van Lieshout, J. J.

AU - Wieling, W.

AU - Settels, J. J.

AU - Karemaker, J. M.

PY - 1991

Y1 - 1991

N2 - In a patient with tetanus we tested the hypothesis that the hyperadrenergic cardiovascular instability might be due to impairment of the baroreceptor reflex by the tetanus toxin. Baroreflex sensitivity assessed with the phenylephrine method was found to be normal. Changes in arterial pressure correlated inversely with relative changes in plasma volume but not with plasma catecholamine levels. There were both extreme hypo- and hyper-adrenergic episodes. We conclude that sympathetic overactivity in tetanus temporarily overrules a functionally intact baroreflex leading to severe blood pressure instability with episodes of hypertension

AB - In a patient with tetanus we tested the hypothesis that the hyperadrenergic cardiovascular instability might be due to impairment of the baroreceptor reflex by the tetanus toxin. Baroreflex sensitivity assessed with the phenylephrine method was found to be normal. Changes in arterial pressure correlated inversely with relative changes in plasma volume but not with plasma catecholamine levels. There were both extreme hypo- and hyper-adrenergic episodes. We conclude that sympathetic overactivity in tetanus temporarily overrules a functionally intact baroreflex leading to severe blood pressure instability with episodes of hypertension

M3 - Article

C2 - 1821666

SN - 0959-9851

VL - 1

SP - 5

EP - 8

JO - CLINICAL AUTONOMIC RESEARCH

JF - CLINICAL AUTONOMIC RESEARCH

IS - 1

ER -