Catechol-O-methyltransferase Val158Met and the Risk of Dyskinesias in Parkinson's Disease

Lonneke M. L. de Lau; Dagmar Verbaan; Johan Marinus; Peter Heutink; Jacobus J. van Hilten

doi:https://doi.org/10.1002/mds.23805

Catechol-O-methyltransferase Val158Met and the Risk of Dyskinesias in Parkinson's Disease

Lonneke M. L. de Lau, Dagmar Verbaan, Johan Marinus, Peter Heutink, Jacobus J. van Hilten

Human Genetics (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

66 Citations (Scopus)

Abstract

Background: The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations. Results: The A-allele of the COMT Val158Met polymorphism was related to an increased risk of developing dyskinesias during follow-up, in a dose-dependent manner (adjusted hazard ratios for the AG and AA genotypes [compared to GG]: 2.09 [95% confidence interval (CI), 1.07-4.06] and 2.81 [CI, 1.43-5.54], respectively). Conclusions: This finding suggests that genetic factors may affect susceptibility to dyskinesias in PD. (C) 2011 Movement Disorder Society

Original language	English
Pages (from-to)	132-135
Journal	Movement disorders
Volume	27
Issue number	1
DOIs	https://doi.org/10.1002/mds.23805
Publication status	Published - 2012

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https://doi.org/10.1002/mds.23805

Cite this

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title = "Catechol-O-methyltransferase Val158Met and the Risk of Dyskinesias in Parkinson's Disease",

abstract = "Background: The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations. Results: The A-allele of the COMT Val158Met polymorphism was related to an increased risk of developing dyskinesias during follow-up, in a dose-dependent manner (adjusted hazard ratios for the AG and AA genotypes [compared to GG]: 2.09 [95% confidence interval (CI), 1.07-4.06] and 2.81 [CI, 1.43-5.54], respectively). Conclusions: This finding suggests that genetic factors may affect susceptibility to dyskinesias in PD. (C) 2011 Movement Disorder Society",

author = "{de Lau}, {Lonneke M. L.} and Dagmar Verbaan and Johan Marinus and Peter Heutink and {van Hilten}, {Jacobus J.}",

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journal = "Movement disorders",

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T1 - Catechol-O-methyltransferase Val158Met and the Risk of Dyskinesias in Parkinson's Disease

AU - de Lau, Lonneke M. L.

AU - Verbaan, Dagmar

AU - Marinus, Johan

AU - Heutink, Peter

AU - van Hilten, Jacobus J.

PY - 2012

Y1 - 2012

N2 - Background: The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations. Results: The A-allele of the COMT Val158Met polymorphism was related to an increased risk of developing dyskinesias during follow-up, in a dose-dependent manner (adjusted hazard ratios for the AG and AA genotypes [compared to GG]: 2.09 [95% confidence interval (CI), 1.07-4.06] and 2.81 [CI, 1.43-5.54], respectively). Conclusions: This finding suggests that genetic factors may affect susceptibility to dyskinesias in PD. (C) 2011 Movement Disorder Society

AB - Background: The A-allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with decreased enzymatic activity and higher dopamine availability. Methods: We studied 219 patients with PD who were free of dyskinesias at baseline and underwent thorough annual examinations. Results: The A-allele of the COMT Val158Met polymorphism was related to an increased risk of developing dyskinesias during follow-up, in a dose-dependent manner (adjusted hazard ratios for the AG and AA genotypes [compared to GG]: 2.09 [95% confidence interval (CI), 1.07-4.06] and 2.81 [CI, 1.43-5.54], respectively). Conclusions: This finding suggests that genetic factors may affect susceptibility to dyskinesias in PD. (C) 2011 Movement Disorder Society

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DO - https://doi.org/10.1002/mds.23805

M3 - Article

C2 - 22083803

SN - 0885-3185

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