Causas, efeitos e alterações de conectividade no declínio relacionado à esclerose múltipla

Translated title of the contribution: Causes, effects and connectivity changes in MS-related cognitive decline

Carolina de Medeiros Rimkus, Martijn D. Steenwijk, Frederik Barkhof

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)


Cognitive decline is a frequent but undervalued aspect of multiple sclerosis (MS). Currently, it remains unclear what the strongest determinants of cognitive dysfunction are, with grey matter damage most directly related to cognitive impairment. Multi-parametric studies seem to indicate that individual factors of MS-pathology are highly interdependent causes of grey matter atrophy and permanent brain damage. They are associated with intermediate functional effects (e.g. in functional MRI) representing a balance between disconnection and (mal) adaptive connectivity changes. Therefore, a more comprehensive MRI approach is warranted, aiming to link structural changes with functional brain organization. To better understand the disconnection syndromes and cognitive decline in MS, this paper reviews the associations between MRI metrics and cognitive performance, by discussing the interactions between multiple facets of MS pathology as determinants of brain damage and how they affect network efficiency.

Translated title of the contributionCauses, effects and connectivity changes in MS-related cognitive decline
Original languagePortuguese
Pages (from-to)2-11
Number of pages10
JournalDementia e Neuropsychologia
Issue number1
Publication statusPublished - 1 Jan 2016


  • Brain mapping
  • Cognition
  • Diffusion tensor imaging
  • Functional neuroimaging
  • Multiple sclerosis

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