TY - JOUR
T1 - Linking resting state metabolite concentrations in the dorsal anterior cingulate cortex to response inhibition in OCD, a combined fMRI-MRS study
AU - de Joode, Niels T.
AU - Thorsen, Anders L.
AU - Vriend, Chris
AU - Pouwels, Petra J. W.
AU - van Balkom, Anton J. L. M.
AU - Hagen, Kristen
AU - Ousdal, Olga T.
AU - Hansen, Bjarne
AU - Kvale, Gerd
AU - van den Heuvel, Odile A.
N1 - Funding Information: This study was supported by the Helse Vest Health Authority (Grant Nos. 911754 and 911880 [to GK]). ALT was supported by a travel grant from the Faculty of Psychology , University of Bergen, Bergen, Norway, when this work was carried out. NTdJ was paid by the VIDI grant from The Netherlands Organization for Health Research (ZonMw) to OAvdH (project number: 91717306 ). Publisher Copyright: © 2023 The Author(s)
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Introduction: Obsessive-compulsive disorder (OCD) has been associated with abnormal brain activation in regions related to response inhibition, such as the dorsal anterior cingulate cortex (dACC), as well as dysregulation of the glutamate system. We studied how the neurometabolites glutamate and glutamine (Glx) in the dACC are related to task performance and task-related brain activation during a response inhibition task in OCD patients and healthy controls (HC). Methods: We combined resting-state magnetic resonance spectroscopy (1H-MRS) in the dACC and functional MRI (fMRI) during the Stop Signal Task (SST), using data from two sites (43 OCD patients and 41 HC). For fMRI data, region of interest (ROI) and whole brain analyses were performed during successful inhibition and error processing. Subsequently, the relation between baseline Glx concentrations, task-related activation, functional connectivity, and task performance was tested using correlational analyses. Results: In HC, Glx concentration in dACC showed a positive correlation with inhibition-related activation in the right thalamus (based on ROI analyses) and the brain stem (based on whole brain analyses). No relation between Glx and task-related activation was observed in patients with OCD. SST performance was not different between groups and was not associated with dACC Glx concentrations. Limitations: Although we attempted to link neurometabolite levels and brain activation, the non-simultaneous acquisition of 1H-MRS with fMRI made it difficult to interpret the results. Conclusions: We conclude that dACC Glx is associated with inhibition-related activation and network function in HC, but not in OCD, suggesting altered inhibition processing in OCD.
AB - Introduction: Obsessive-compulsive disorder (OCD) has been associated with abnormal brain activation in regions related to response inhibition, such as the dorsal anterior cingulate cortex (dACC), as well as dysregulation of the glutamate system. We studied how the neurometabolites glutamate and glutamine (Glx) in the dACC are related to task performance and task-related brain activation during a response inhibition task in OCD patients and healthy controls (HC). Methods: We combined resting-state magnetic resonance spectroscopy (1H-MRS) in the dACC and functional MRI (fMRI) during the Stop Signal Task (SST), using data from two sites (43 OCD patients and 41 HC). For fMRI data, region of interest (ROI) and whole brain analyses were performed during successful inhibition and error processing. Subsequently, the relation between baseline Glx concentrations, task-related activation, functional connectivity, and task performance was tested using correlational analyses. Results: In HC, Glx concentration in dACC showed a positive correlation with inhibition-related activation in the right thalamus (based on ROI analyses) and the brain stem (based on whole brain analyses). No relation between Glx and task-related activation was observed in patients with OCD. SST performance was not different between groups and was not associated with dACC Glx concentrations. Limitations: Although we attempted to link neurometabolite levels and brain activation, the non-simultaneous acquisition of 1H-MRS with fMRI made it difficult to interpret the results. Conclusions: We conclude that dACC Glx is associated with inhibition-related activation and network function in HC, but not in OCD, suggesting altered inhibition processing in OCD.
KW - 1H-MRS
KW - Stop signal task
KW - fMRI
KW - glutamate+glutamine (Glx)
KW - obsessive-compulsive disorder
KW - response Inhibition
UR - http://www.scopus.com/inward/record.url?scp=85167792362&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.jadr.2023.100641
DO - https://doi.org/10.1016/j.jadr.2023.100641
M3 - Article
SN - 2666-9153
VL - 14
JO - Journal of Affective Disorders Reports
JF - Journal of Affective Disorders Reports
M1 - 100641
ER -