Cell-associated HIV RNA: a dynamic biomarker of viral persistence

Alexander O. Pasternak; Vladimir V. Lukashov; Ben Berkhout

doi:https://doi.org/10.1186/1742-4690-10-41

Cell-associated HIV RNA: a dynamic biomarker of viral persistence

Alexander O. Pasternak, Vladimir V. Lukashov, Ben Berkhout

Research output: Contribution to journal › Review article › Academic › peer-review

99 Citations (Scopus)

Abstract

In most HIV-infected individuals adherent to modern antiretroviral therapy (ART), plasma viremia stays undetectable by clinical assays and therefore, additional virological markers for monitoring and predicting therapy responses and for measuring the degree of HIV persistence in patients on ART should be identified. For the above purposes, quantitation of cell-associated HIV biomarkers could provide a useful alternative to measurements of viral RNA in plasma. This review concentrates on cell-associated (CA) HIV RNA with the emphasis on its use as a virological biomarker. We discuss the significance of CA HIV RNA as a prognostic marker of disease progression in untreated patients and as an indicator of residual virus replication and the size of the dynamic viral reservoir in ART-treated patients. Potential value of this biomarker for monitoring the response to ART and to novel HIV eradication therapies is highlighted

Original language	English
Pages (from-to)	41
Journal	Retrovirology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/1742-4690-10-41
Publication status	Published - 2013

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https://doi.org/10.1186/1742-4690-10-41

Cite this

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title = "Cell-associated HIV RNA: a dynamic biomarker of viral persistence",

abstract = "In most HIV-infected individuals adherent to modern antiretroviral therapy (ART), plasma viremia stays undetectable by clinical assays and therefore, additional virological markers for monitoring and predicting therapy responses and for measuring the degree of HIV persistence in patients on ART should be identified. For the above purposes, quantitation of cell-associated HIV biomarkers could provide a useful alternative to measurements of viral RNA in plasma. This review concentrates on cell-associated (CA) HIV RNA with the emphasis on its use as a virological biomarker. We discuss the significance of CA HIV RNA as a prognostic marker of disease progression in untreated patients and as an indicator of residual virus replication and the size of the dynamic viral reservoir in ART-treated patients. Potential value of this biomarker for monitoring the response to ART and to novel HIV eradication therapies is highlighted",

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T1 - Cell-associated HIV RNA: a dynamic biomarker of viral persistence

AU - Pasternak, Alexander O.

AU - Lukashov, Vladimir V.

AU - Berkhout, Ben

PY - 2013

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N2 - In most HIV-infected individuals adherent to modern antiretroviral therapy (ART), plasma viremia stays undetectable by clinical assays and therefore, additional virological markers for monitoring and predicting therapy responses and for measuring the degree of HIV persistence in patients on ART should be identified. For the above purposes, quantitation of cell-associated HIV biomarkers could provide a useful alternative to measurements of viral RNA in plasma. This review concentrates on cell-associated (CA) HIV RNA with the emphasis on its use as a virological biomarker. We discuss the significance of CA HIV RNA as a prognostic marker of disease progression in untreated patients and as an indicator of residual virus replication and the size of the dynamic viral reservoir in ART-treated patients. Potential value of this biomarker for monitoring the response to ART and to novel HIV eradication therapies is highlighted

AB - In most HIV-infected individuals adherent to modern antiretroviral therapy (ART), plasma viremia stays undetectable by clinical assays and therefore, additional virological markers for monitoring and predicting therapy responses and for measuring the degree of HIV persistence in patients on ART should be identified. For the above purposes, quantitation of cell-associated HIV biomarkers could provide a useful alternative to measurements of viral RNA in plasma. This review concentrates on cell-associated (CA) HIV RNA with the emphasis on its use as a virological biomarker. We discuss the significance of CA HIV RNA as a prognostic marker of disease progression in untreated patients and as an indicator of residual virus replication and the size of the dynamic viral reservoir in ART-treated patients. Potential value of this biomarker for monitoring the response to ART and to novel HIV eradication therapies is highlighted

U2 - https://doi.org/10.1186/1742-4690-10-41

DO - https://doi.org/10.1186/1742-4690-10-41

M3 - Review article

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SN - 1742-4690

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SP - 41

JO - Retrovirology

JF - Retrovirology

IS - 1

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